Interleukin-17: A Promoter in Colorectal Cancer Progression

It is widely accepted that chronic inflammation plays an active role in cancer. Inflammatory immunocytes and related cytokines in the tumor microenvironment are supposed to be a “double-edged sword” in colorectal cancer (CRC) initiation and progression. Interleukin-17 (IL-17), a pleiotropic proinfla...

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Detalles Bibliográficos
Autores principales: Wu, Dang, Wu, Pin, Huang, Qi, Liu, Yang, Ye, Jun, Huang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870650/
https://www.ncbi.nlm.nih.gov/pubmed/24382972
http://dx.doi.org/10.1155/2013/436307
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author Wu, Dang
Wu, Pin
Huang, Qi
Liu, Yang
Ye, Jun
Huang, Jian
author_facet Wu, Dang
Wu, Pin
Huang, Qi
Liu, Yang
Ye, Jun
Huang, Jian
author_sort Wu, Dang
collection PubMed
description It is widely accepted that chronic inflammation plays an active role in cancer. Inflammatory immunocytes and related cytokines in the tumor microenvironment are supposed to be a “double-edged sword” in colorectal cancer (CRC) initiation and progression. Interleukin-17 (IL-17), a pleiotropic proinflammatory cytokine, can promote cancer-elicited inflammation and prevent cancer cells from immune surveillance. Despite controversy, IL-17 is generally considered to be a promoter in CRC progression. In this review, we devote to summarize the current progress regarding the role of IL-17 in tumor initiation and progression, as well as the prognostic value in CRC.
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spelling pubmed-38706502014-01-01 Interleukin-17: A Promoter in Colorectal Cancer Progression Wu, Dang Wu, Pin Huang, Qi Liu, Yang Ye, Jun Huang, Jian Clin Dev Immunol Review Article It is widely accepted that chronic inflammation plays an active role in cancer. Inflammatory immunocytes and related cytokines in the tumor microenvironment are supposed to be a “double-edged sword” in colorectal cancer (CRC) initiation and progression. Interleukin-17 (IL-17), a pleiotropic proinflammatory cytokine, can promote cancer-elicited inflammation and prevent cancer cells from immune surveillance. Despite controversy, IL-17 is generally considered to be a promoter in CRC progression. In this review, we devote to summarize the current progress regarding the role of IL-17 in tumor initiation and progression, as well as the prognostic value in CRC. Hindawi Publishing Corporation 2013 2013-12-07 /pmc/articles/PMC3870650/ /pubmed/24382972 http://dx.doi.org/10.1155/2013/436307 Text en Copyright © 2013 Dang Wu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wu, Dang
Wu, Pin
Huang, Qi
Liu, Yang
Ye, Jun
Huang, Jian
Interleukin-17: A Promoter in Colorectal Cancer Progression
title Interleukin-17: A Promoter in Colorectal Cancer Progression
title_full Interleukin-17: A Promoter in Colorectal Cancer Progression
title_fullStr Interleukin-17: A Promoter in Colorectal Cancer Progression
title_full_unstemmed Interleukin-17: A Promoter in Colorectal Cancer Progression
title_short Interleukin-17: A Promoter in Colorectal Cancer Progression
title_sort interleukin-17: a promoter in colorectal cancer progression
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870650/
https://www.ncbi.nlm.nih.gov/pubmed/24382972
http://dx.doi.org/10.1155/2013/436307
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AT yejun interleukin17apromoterincolorectalcancerprogression
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