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The prognostic role of PRUNE2 in leiomyosarcoma
PRUNE2 plays an important role in regulating tumor cell differentiation, proliferation, and invasiveness in neuroblastoma. Our previous study revealed that PRUNE2/OBSCN two-gene relative expression classifer accurately differentiated leiomyosarcoma from gastrointestinal stromal tumor. However, the a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sun Yat-sen University Cancer Center
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870848/ https://www.ncbi.nlm.nih.gov/pubmed/23731771 http://dx.doi.org/10.5732/cjc.013.10069 |
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author | Zhao, Lin-Ru Tian, Wei Wang, Guo-Wen Chen, Ke-Xin Yang, Ji-Long |
author_facet | Zhao, Lin-Ru Tian, Wei Wang, Guo-Wen Chen, Ke-Xin Yang, Ji-Long |
author_sort | Zhao, Lin-Ru |
collection | PubMed |
description | PRUNE2 plays an important role in regulating tumor cell differentiation, proliferation, and invasiveness in neuroblastoma. Our previous study revealed that PRUNE2/OBSCN two-gene relative expression classifer accurately differentiated leiomyosarcoma from gastrointestinal stromal tumor. However, the association between PRUNE2 expression and prognosis in leiomyosarcoma is poorly understood. In this study, we evaluated the prognostic role of PRUNE2 in leiomyosarcoma. PRUNE2 expression was detected using immunohistochemistry in 30 formalin-fixed, paraffin-embedded leiomyosarcoma tissues from MD Anderson Cancer Center, and high expression was detected in 36.7% (11/30) of the samples. To validate these results, immunohistochemistry was performed on another cohort of 45 formalin-fixed, paraffin-embedded leiomyosarcoma tissues from Tianjin Medical University Cancer Institute & Hospital, and high PRUNE2 protein expression was detected in 37.8% (17/45) of the samples. Moreover, elevated PRUNE2 expression was significantly associated with tumor size (P = 0.03) and hemorrhage/cyst (P = 0.014), and was an independent favorable prognostic factor for overall survival in leiomyosarcoma patients from Tianjin Medical University Cancer Institute & Hospital (P < 0.05). These data suggest that increased PRUNE2 protein expression may serve as a favorable prognostic marker in human leiomyosarcoma. |
format | Online Article Text |
id | pubmed-3870848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Sun Yat-sen University Cancer Center |
record_format | MEDLINE/PubMed |
spelling | pubmed-38708482013-12-31 The prognostic role of PRUNE2 in leiomyosarcoma Zhao, Lin-Ru Tian, Wei Wang, Guo-Wen Chen, Ke-Xin Yang, Ji-Long Chin J Cancer Original Article PRUNE2 plays an important role in regulating tumor cell differentiation, proliferation, and invasiveness in neuroblastoma. Our previous study revealed that PRUNE2/OBSCN two-gene relative expression classifer accurately differentiated leiomyosarcoma from gastrointestinal stromal tumor. However, the association between PRUNE2 expression and prognosis in leiomyosarcoma is poorly understood. In this study, we evaluated the prognostic role of PRUNE2 in leiomyosarcoma. PRUNE2 expression was detected using immunohistochemistry in 30 formalin-fixed, paraffin-embedded leiomyosarcoma tissues from MD Anderson Cancer Center, and high expression was detected in 36.7% (11/30) of the samples. To validate these results, immunohistochemistry was performed on another cohort of 45 formalin-fixed, paraffin-embedded leiomyosarcoma tissues from Tianjin Medical University Cancer Institute & Hospital, and high PRUNE2 protein expression was detected in 37.8% (17/45) of the samples. Moreover, elevated PRUNE2 expression was significantly associated with tumor size (P = 0.03) and hemorrhage/cyst (P = 0.014), and was an independent favorable prognostic factor for overall survival in leiomyosarcoma patients from Tianjin Medical University Cancer Institute & Hospital (P < 0.05). These data suggest that increased PRUNE2 protein expression may serve as a favorable prognostic marker in human leiomyosarcoma. Sun Yat-sen University Cancer Center 2013-12 /pmc/articles/PMC3870848/ /pubmed/23731771 http://dx.doi.org/10.5732/cjc.013.10069 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission. |
spellingShingle | Original Article Zhao, Lin-Ru Tian, Wei Wang, Guo-Wen Chen, Ke-Xin Yang, Ji-Long The prognostic role of PRUNE2 in leiomyosarcoma |
title | The prognostic role of PRUNE2 in leiomyosarcoma |
title_full | The prognostic role of PRUNE2 in leiomyosarcoma |
title_fullStr | The prognostic role of PRUNE2 in leiomyosarcoma |
title_full_unstemmed | The prognostic role of PRUNE2 in leiomyosarcoma |
title_short | The prognostic role of PRUNE2 in leiomyosarcoma |
title_sort | prognostic role of prune2 in leiomyosarcoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870848/ https://www.ncbi.nlm.nih.gov/pubmed/23731771 http://dx.doi.org/10.5732/cjc.013.10069 |
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