The Effect of Safflower Yellow on Spinal Cord Ischemia Reperfusion Injury in Rabbits

Safflower yellow (SY) is the safflower extract and is the one of traditional Chinese medicine. The aim of the present work was to investigate the effect of SY on spinal cord ischemia reperfusion injury (SCIRI) in rabbits. The models of spinal cord ischemia reperfusion (SI/R) were constructed, and th...

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Autores principales: Zhou, Daiwei, Liu, Bingbing, Xiao, Xiaoshan, Dai, Peng, Ma, Songmei, Huang, Weihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870863/
https://www.ncbi.nlm.nih.gov/pubmed/24381717
http://dx.doi.org/10.1155/2013/692302
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author Zhou, Daiwei
Liu, Bingbing
Xiao, Xiaoshan
Dai, Peng
Ma, Songmei
Huang, Weihua
author_facet Zhou, Daiwei
Liu, Bingbing
Xiao, Xiaoshan
Dai, Peng
Ma, Songmei
Huang, Weihua
author_sort Zhou, Daiwei
collection PubMed
description Safflower yellow (SY) is the safflower extract and is the one of traditional Chinese medicine. The aim of the present work was to investigate the effect of SY on spinal cord ischemia reperfusion injury (SCIRI) in rabbits. The models of spinal cord ischemia reperfusion (SI/R) were constructed, and the degree of the post-ischemic injury was assessed by means of the neurological deficit scores and plasma levels of lipid peroxidation reactioin and neuronal morphologic changes. SCIRI remarkably affected the functional activities of the hind limbs and activated lipid peroxidation reaction. SY could attenuate apoptosis and SCIRI by enhancing Bcl-2 expression and inhibiting Bax and caspase-3 activation.
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spelling pubmed-38708632013-12-31 The Effect of Safflower Yellow on Spinal Cord Ischemia Reperfusion Injury in Rabbits Zhou, Daiwei Liu, Bingbing Xiao, Xiaoshan Dai, Peng Ma, Songmei Huang, Weihua Oxid Med Cell Longev Research Article Safflower yellow (SY) is the safflower extract and is the one of traditional Chinese medicine. The aim of the present work was to investigate the effect of SY on spinal cord ischemia reperfusion injury (SCIRI) in rabbits. The models of spinal cord ischemia reperfusion (SI/R) were constructed, and the degree of the post-ischemic injury was assessed by means of the neurological deficit scores and plasma levels of lipid peroxidation reactioin and neuronal morphologic changes. SCIRI remarkably affected the functional activities of the hind limbs and activated lipid peroxidation reaction. SY could attenuate apoptosis and SCIRI by enhancing Bcl-2 expression and inhibiting Bax and caspase-3 activation. Hindawi Publishing Corporation 2013 2013-12-07 /pmc/articles/PMC3870863/ /pubmed/24381717 http://dx.doi.org/10.1155/2013/692302 Text en Copyright © 2013 Daiwei Zhou et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhou, Daiwei
Liu, Bingbing
Xiao, Xiaoshan
Dai, Peng
Ma, Songmei
Huang, Weihua
The Effect of Safflower Yellow on Spinal Cord Ischemia Reperfusion Injury in Rabbits
title The Effect of Safflower Yellow on Spinal Cord Ischemia Reperfusion Injury in Rabbits
title_full The Effect of Safflower Yellow on Spinal Cord Ischemia Reperfusion Injury in Rabbits
title_fullStr The Effect of Safflower Yellow on Spinal Cord Ischemia Reperfusion Injury in Rabbits
title_full_unstemmed The Effect of Safflower Yellow on Spinal Cord Ischemia Reperfusion Injury in Rabbits
title_short The Effect of Safflower Yellow on Spinal Cord Ischemia Reperfusion Injury in Rabbits
title_sort effect of safflower yellow on spinal cord ischemia reperfusion injury in rabbits
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870863/
https://www.ncbi.nlm.nih.gov/pubmed/24381717
http://dx.doi.org/10.1155/2013/692302
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