Cargando…

Parkinson’s disease: dopaminergic nerve cell model is consistent with experimental finding of increased extracellular transport of α-synuclein

BACKGROUND: Parkinson’s disease is an age-related disease whose pathogenesis is not completely known. Animal models exist for investigating the disease but not all results can be easily transferred to humans. Therefore, mathematical or probabilistic models for the human disease are to be constructed...

Descripción completa

Detalles Bibliográficos
Autores principales:	Büchel, Finja, Saliger, Sandra, Dräger, Andreas, Hoffmann, Stephanie, Wrzodek, Clemens, Zell, Andreas, Kahle, Philipp J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871002/ https://www.ncbi.nlm.nih.gov/pubmed/24195591 http://dx.doi.org/10.1186/1471-2202-14-136

Ejemplares similares

Precise generation of systems biology models from KEGG pathways
por: Wrzodek, Clemens, et al.
Publicado: (2013)

InCroMAP: integrated analysis of cross-platform microarray and pathway data
por: Wrzodek, Clemens, et al.
Publicado: (2013)

ZBIT Bioinformatics Toolbox: A Web-Platform for Systems Biology and Expression Data Analysis
por: Römer, Michael, et al.
Publicado: (2016)

Qualitative translation of relations from BioPAX to SBML qual
por: Büchel, Finja, et al.
Publicado: (2012)

Linking the Epigenome to the Genome: Correlation of Different Features to DNA Methylation of CpG Islands
por: Wrzodek, Clemens, et al.
Publicado: (2012)

Integrative Pathway-Based Approach for Genome-Wide Association Studies: Identification of New Pathways for Rheumatoid Arthritis and Type 1 Diabetes
por: Büchel, Finja, et al.
Publicado: (2013)

KEGGtranslator: visualizing and converting the KEGG PATHWAY database to various formats
por: Wrzodek, Clemens, et al.
Publicado: (2011)

TFpredict and SABINE: Sequence-Based Prediction of Structural and Functional Characteristics of Transcription Factors
por: Eichner, Johannes, et al.
Publicado: (2013)

JSBML: a flexible Java library for working with SBML
por: Dräger, Andreas, et al.
Publicado: (2011)

Evaluation of Toxicogenomics Approaches for Assessing the Risk of Nongenotoxic Carcinogenicity in Rat Liver
por: Eichner, Johannes, et al.
Publicado: (2014)

Path2Models: large-scale generation of computational models from biochemical pathway maps
por: Büchel, Finja, et al.
Publicado: (2013)

The Convergence of Alpha-Synuclein, Mitochondrial, and Lysosomal Pathways in Vulnerability of Midbrain Dopaminergic Neurons in Parkinson’s Disease
por: Minakaki, Georgia, et al.
Publicado: (2020)

BMP5/7 protect dopaminergic neurons in an α-synuclein mouse model of Parkinson’s disease
por: Vitic, Zagorka, et al.
Publicado: (2020)

Optogenetic induction of alpha-synuclein aggregation in human dopaminergic neurons to model Parkinson’s disease pathology
por: Ra, Eun A., et al.
Publicado: (2023)

Dyrk1a Phosphorylation of α-Synuclein Mediating Apoptosis of Dopaminergic Neurons in Parkinson's Disease
por: Yong, Yuxuan, et al.
Publicado: (2023)

A Toxicogenomic Approach for the Prediction of Murine Hepatocarcinogenesis Using Ensemble Feature Selection
por: Eichner, Johannes, et al.
Publicado: (2013)

Chronic–Progressive Dopaminergic Deficiency Does Not Induce Midbrain Neurogenesis
por: Fauser, Mareike, et al.
Publicado: (2021)

SBMLSimulator: A Java Tool for Model Simulation and Parameter Estimation in Systems Biology
por: Dörr, Alexander, et al.
Publicado: (2014)

Mechanistic impacts of bacterial diet on dopaminergic neurodegeneration in a Caenorhabditis elegans α-synuclein model of Parkinson’s disease
por: Gaeta, Anthony L., et al.
Publicado: (2023)

Inflammasome inhibition protects dopaminergic neurons from α-synuclein pathology in a model of progressive Parkinson’s disease
por: Grotemeyer, Alexander, et al.
Publicado: (2023)

IGF2 prevents dopaminergic neuronal loss and decreases intracellular alpha-synuclein accumulation in Parkinson’s disease models
por: Arcos, Javiera, et al.
Publicado: (2023)

Plasma Extracellular Vesicle α-Synuclein Level in Patients with Parkinson’s Disease
por: Chung, Chen-Chih, et al.
Publicado: (2021)

α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis
por: Wang, Pan, et al.
Publicado: (2023)

JSBML 1.0: providing a smorgasbord of options to encode systems biology models
por: Rodriguez, Nicolas, et al.
Publicado: (2015)

n-Butylidenephthalide Protects against Dopaminergic Neuron Degeneration and α-Synuclein Accumulation in Caenorhabditis elegans Models of Parkinson's Disease
por: Fu, Ru-Huei, et al.
Publicado: (2014)

Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson’s disease mouse model
por: Lv, Yi-Qing, et al.
Publicado: (2022)

Phenotypic manifestation of α-synuclein strains derived from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons
por: Tanudjojo, Benedict, et al.
Publicado: (2021)

Dopaminergic Positron Emission Tomography Imaging in the Alpha‐Synuclein Preformed Fibril Model Reveals Similarities to Early Parkinson's Disease
por: Sossi, Vesna, et al.
Publicado: (2022)

Nicotine-Mediated Recruitment of GABAergic Neurons to a Dopaminergic Phenotype Attenuates Motor Deficits in an Alpha-Synuclein Parkinson’s Model
por: Lai, Jessica IChi, et al.
Publicado: (2023)

Pharmacologic inhibition of NLRP3 reduces the levels of α-synuclein and protects dopaminergic neurons in a model of Parkinson’s disease
por: Amo-Aparicio, Jesus, et al.
Publicado: (2023)

Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein
por: McKinnon, Chris, et al.
Publicado: (2020)

The couple of netrin-1/α-Synuclein regulates the survival of dopaminergic neurons via α-Synuclein disaggregation
por: Kang, Eun Ji, et al.
Publicado: (2023)

SBMLsqueezer: A CellDesigner plug-in to generate kinetic rate equations for biochemical networks
por: Dräger, Andreas, et al.
Publicado: (2008)

TDP-43 regulates global translational yield by splicing of exon junction complex component SKAR
por: Fiesel, Fabienne C., et al.
Publicado: (2012)

Irisflorentin improves α-synuclein accumulation and attenuates 6-OHDA-induced dopaminergic neuron degeneration, implication for Parkinson’s disease therapy
por: Chen, Yue-Mi, et al.
Publicado: (2015)

The SUMO Conjugase Ubc9 Protects Dopaminergic Cells from Cytotoxicity and Enhances the Stability of α-Synuclein in Parkinson’s Disease Models
por: Verma, Dinesh Kumar, et al.
Publicado: (2020)

NXP031 prevents dopaminergic neuronal loss and oxidative damage in the AAV-WT-α-synuclein mouse model of Parkinson’s disease
por: Song, Min Kyung, et al.
Publicado: (2022)

Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration
por: Van Rompuy, Anne-Sophie, et al.
Publicado: (2015)

Parkinson's disease and dopaminergic neurons
Publicado: (2012)

Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons
por: Benner, Eric J., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_3v51rubkcn78v2d3reiklqvsbk