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The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct binding
BACKGROUND: The WW domain containing protein WWOX has been postulated to behave as a tumor suppressor in breast and other cancers. Expression of this protein is lost in over 70% of ER negative tumors. This prompted us to investigate the phenotypic and gene expression effects of loss of WWOX expressi...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871008/ https://www.ncbi.nlm.nih.gov/pubmed/24330518 http://dx.doi.org/10.1186/1471-2407-13-593 |