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Rhabdomyolysis and Acute Kidney Injury Associated with Hypothyroidism and Statin Therapy

Rhabdomyolysis is a syndrome involving the breakdown of skeletal muscle that causes myoglobin and other intracellular proteins to leak into the circulatory system, resulting in organ injury including acute kidney injury. We report a case of statin-induced rhabdomyolysis and acute kidney injury that...

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Autores principales: Ahn, Pyoung, Min, Hyun-Jun, Park, Sang-Hyun, Lee, Byoung-Mu, Choi, Myung-Jin, Yoon, Jong-Woo, Koo, Ja-Ryong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Endocrine Society 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871041/
https://www.ncbi.nlm.nih.gov/pubmed/24396699
http://dx.doi.org/10.3803/EnM.2013.28.4.331
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author Ahn, Pyoung
Min, Hyun-Jun
Park, Sang-Hyun
Lee, Byoung-Mu
Choi, Myung-Jin
Yoon, Jong-Woo
Koo, Ja-Ryong
author_facet Ahn, Pyoung
Min, Hyun-Jun
Park, Sang-Hyun
Lee, Byoung-Mu
Choi, Myung-Jin
Yoon, Jong-Woo
Koo, Ja-Ryong
author_sort Ahn, Pyoung
collection PubMed
description Rhabdomyolysis is a syndrome involving the breakdown of skeletal muscle that causes myoglobin and other intracellular proteins to leak into the circulatory system, resulting in organ injury including acute kidney injury. We report a case of statin-induced rhabdomyolysis and acute kidney injury that developed in a 63-year-old woman with previously undiagnosed hypothyroidism. Untreated hypothyroidism may have caused her hypercholesterolemia requiring statin treatment, and it is postulated that statin-induced muscle injury was aggravated by hypothyroidism resulting in her full-blown rhabdomyolysis. Although this patient was successfully treated with continuous venovenous hemofiltration and L-thyroxin replacement, rhabdomyolysis with acute kidney injury is a potentially life-threatening disorder. Physicians must pay special attention to the possible presence of subclinical hypothyroidism when administering statins in patients with hypercholesterolemia.
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spelling pubmed-38710412014-01-06 Rhabdomyolysis and Acute Kidney Injury Associated with Hypothyroidism and Statin Therapy Ahn, Pyoung Min, Hyun-Jun Park, Sang-Hyun Lee, Byoung-Mu Choi, Myung-Jin Yoon, Jong-Woo Koo, Ja-Ryong Endocrinol Metab (Seoul) Case Report Rhabdomyolysis is a syndrome involving the breakdown of skeletal muscle that causes myoglobin and other intracellular proteins to leak into the circulatory system, resulting in organ injury including acute kidney injury. We report a case of statin-induced rhabdomyolysis and acute kidney injury that developed in a 63-year-old woman with previously undiagnosed hypothyroidism. Untreated hypothyroidism may have caused her hypercholesterolemia requiring statin treatment, and it is postulated that statin-induced muscle injury was aggravated by hypothyroidism resulting in her full-blown rhabdomyolysis. Although this patient was successfully treated with continuous venovenous hemofiltration and L-thyroxin replacement, rhabdomyolysis with acute kidney injury is a potentially life-threatening disorder. Physicians must pay special attention to the possible presence of subclinical hypothyroidism when administering statins in patients with hypercholesterolemia. Korean Endocrine Society 2013-12 2013-12-12 /pmc/articles/PMC3871041/ /pubmed/24396699 http://dx.doi.org/10.3803/EnM.2013.28.4.331 Text en Copyright © 2013 Korean Endocrine Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ahn, Pyoung
Min, Hyun-Jun
Park, Sang-Hyun
Lee, Byoung-Mu
Choi, Myung-Jin
Yoon, Jong-Woo
Koo, Ja-Ryong
Rhabdomyolysis and Acute Kidney Injury Associated with Hypothyroidism and Statin Therapy
title Rhabdomyolysis and Acute Kidney Injury Associated with Hypothyroidism and Statin Therapy
title_full Rhabdomyolysis and Acute Kidney Injury Associated with Hypothyroidism and Statin Therapy
title_fullStr Rhabdomyolysis and Acute Kidney Injury Associated with Hypothyroidism and Statin Therapy
title_full_unstemmed Rhabdomyolysis and Acute Kidney Injury Associated with Hypothyroidism and Statin Therapy
title_short Rhabdomyolysis and Acute Kidney Injury Associated with Hypothyroidism and Statin Therapy
title_sort rhabdomyolysis and acute kidney injury associated with hypothyroidism and statin therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871041/
https://www.ncbi.nlm.nih.gov/pubmed/24396699
http://dx.doi.org/10.3803/EnM.2013.28.4.331
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