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Multiple sclerosis impairs regional functional connectivity in the cerebellum()

Resting-state functional magnetic resonance imaging (rs-fMRI) has been used to study changes in long-range functional brain connectivity in multiple sclerosis (MS). Yet little is known about how MS affects functional brain connectivity at the local level. Here we studied 42 patients with MS and 30 m...

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Autores principales: Dogonowski, Anne-Marie, Andersen, Kasper Winther, Madsen, Kristoffer Hougaard, Sørensen, Per Soelberg, Paulson, Olaf Bjarne, Blinkenberg, Morten, Siebner, Hartwig Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871286/
https://www.ncbi.nlm.nih.gov/pubmed/24371795
http://dx.doi.org/10.1016/j.nicl.2013.11.005
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author Dogonowski, Anne-Marie
Andersen, Kasper Winther
Madsen, Kristoffer Hougaard
Sørensen, Per Soelberg
Paulson, Olaf Bjarne
Blinkenberg, Morten
Siebner, Hartwig Roman
author_facet Dogonowski, Anne-Marie
Andersen, Kasper Winther
Madsen, Kristoffer Hougaard
Sørensen, Per Soelberg
Paulson, Olaf Bjarne
Blinkenberg, Morten
Siebner, Hartwig Roman
author_sort Dogonowski, Anne-Marie
collection PubMed
description Resting-state functional magnetic resonance imaging (rs-fMRI) has been used to study changes in long-range functional brain connectivity in multiple sclerosis (MS). Yet little is known about how MS affects functional brain connectivity at the local level. Here we studied 42 patients with MS and 30 matched healthy controls with whole-brain rs-fMRI at 3 T to examine local functional connectivity. Using the Kendall's Coefficient of Concordance, regional homogeneity of blood-oxygen-level-dependent (BOLD)-signal fluctuations was calculated for each voxel and used as a measure of local connectivity. Patients with MS showed a decrease in regional homogeneity in the upper left cerebellar hemisphere in lobules V and VI relative to healthy controls. Similar trend changes in regional homogeneity were present in the right cerebellar hemisphere. The results indicate a disintegration of regional processing in the cerebellum in MS. This might be caused by a functional disruption of cortico-ponto-cerebellar and spino-cerebellar inputs, since patients with higher lesion load in the left cerebellar peduncles showed a stronger reduction in cerebellar homogeneity. In patients, two clusters in the left posterior cerebellum expressed a reduction in regional homogeneity with increasing global disability as reflected by the Expanded Disability Status Scale (EDSS) score or higher ataxia scores. The two clusters were mainly located in Crus I and extended into Crus II and the dentate nucleus but with little spatial overlap. These findings suggest a link between impaired regional integration in the cerebellum and general disability and ataxia.
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spelling pubmed-38712862013-12-26 Multiple sclerosis impairs regional functional connectivity in the cerebellum() Dogonowski, Anne-Marie Andersen, Kasper Winther Madsen, Kristoffer Hougaard Sørensen, Per Soelberg Paulson, Olaf Bjarne Blinkenberg, Morten Siebner, Hartwig Roman Neuroimage Clin Article Resting-state functional magnetic resonance imaging (rs-fMRI) has been used to study changes in long-range functional brain connectivity in multiple sclerosis (MS). Yet little is known about how MS affects functional brain connectivity at the local level. Here we studied 42 patients with MS and 30 matched healthy controls with whole-brain rs-fMRI at 3 T to examine local functional connectivity. Using the Kendall's Coefficient of Concordance, regional homogeneity of blood-oxygen-level-dependent (BOLD)-signal fluctuations was calculated for each voxel and used as a measure of local connectivity. Patients with MS showed a decrease in regional homogeneity in the upper left cerebellar hemisphere in lobules V and VI relative to healthy controls. Similar trend changes in regional homogeneity were present in the right cerebellar hemisphere. The results indicate a disintegration of regional processing in the cerebellum in MS. This might be caused by a functional disruption of cortico-ponto-cerebellar and spino-cerebellar inputs, since patients with higher lesion load in the left cerebellar peduncles showed a stronger reduction in cerebellar homogeneity. In patients, two clusters in the left posterior cerebellum expressed a reduction in regional homogeneity with increasing global disability as reflected by the Expanded Disability Status Scale (EDSS) score or higher ataxia scores. The two clusters were mainly located in Crus I and extended into Crus II and the dentate nucleus but with little spatial overlap. These findings suggest a link between impaired regional integration in the cerebellum and general disability and ataxia. Elsevier 2013-11-27 /pmc/articles/PMC3871286/ /pubmed/24371795 http://dx.doi.org/10.1016/j.nicl.2013.11.005 Text en © 2013 The Authors http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Dogonowski, Anne-Marie
Andersen, Kasper Winther
Madsen, Kristoffer Hougaard
Sørensen, Per Soelberg
Paulson, Olaf Bjarne
Blinkenberg, Morten
Siebner, Hartwig Roman
Multiple sclerosis impairs regional functional connectivity in the cerebellum()
title Multiple sclerosis impairs regional functional connectivity in the cerebellum()
title_full Multiple sclerosis impairs regional functional connectivity in the cerebellum()
title_fullStr Multiple sclerosis impairs regional functional connectivity in the cerebellum()
title_full_unstemmed Multiple sclerosis impairs regional functional connectivity in the cerebellum()
title_short Multiple sclerosis impairs regional functional connectivity in the cerebellum()
title_sort multiple sclerosis impairs regional functional connectivity in the cerebellum()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871286/
https://www.ncbi.nlm.nih.gov/pubmed/24371795
http://dx.doi.org/10.1016/j.nicl.2013.11.005
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