APP Processing in Human Pluripotent Stem Cell-Derived Neurons Is Resistant to NSAID-Based γ-Secretase Modulation

Increasing evidence suggests that elevated Aβ42 fractions in the brain cause Alzheimer’s disease (AD). Although γ-secretase modulators (GSMs), including a set of nonsteroidal anti-inflammatory drugs (NSAIDs), were found to lower Aβ42 in various model systems, NSAID-based GSMs proved to be surprising...

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Detalles Bibliográficos
Autores principales: Mertens, Jerome, Stüber, Kathrin, Wunderlich, Patrick, Ladewig, Julia, Kesavan, Jaideep C., Vandenberghe, Rik, Vandenbulcke, Mathieu, van Damme, Philip, Walter, Jochen, Brüstle, Oliver, Koch, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871388/
https://www.ncbi.nlm.nih.gov/pubmed/24371804
http://dx.doi.org/10.1016/j.stemcr.2013.10.011

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