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PGC-1α and Reactive Oxygen Species Regulate Human Embryonic Stem Cell-Derived Cardiomyocyte Function

Diminished mitochondrial function is causally related to some heart diseases. Here, we developed a human disease model based on cardiomyocytes from human embryonic stem cells (hESCs), in which an important pathway of mitochondrial gene expression was inactivated. Repression of PGC-1α, which is norma...

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Detalles Bibliográficos
Autores principales:	Birket, Matthew J., Casini, Simona, Kosmidis, Georgios, Elliott, David A., Gerencser, Akos A., Baartscheer, Antonius, Schumacher, Cees, Mastroberardino, Pier G., Elefanty, Andrew G., Stanley, Ed G., Mummery, Christine L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871390/ https://www.ncbi.nlm.nih.gov/pubmed/24371810 http://dx.doi.org/10.1016/j.stemcr.2013.11.008

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