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Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis

Tpr is a conserved nuclear pore complex (NPC) protein implicated in the spindle assembly checkpoint (SAC) by an unknown mechanism. Here, we show that Tpr is required for normal SAC response by stabilizing Mad1 and Mad2 before mitosis. Tpr coimmunoprecipitated with Mad1 and Mad2 (hereafter designated...

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Detalles Bibliográficos
Autores principales:	Schweizer, Nina, Ferrás, Cristina, Kern, David M., Logarinho, Elsa, Cheeseman, Iain M., Maiato, Helder
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871433/ https://www.ncbi.nlm.nih.gov/pubmed/24344181 http://dx.doi.org/10.1083/jcb.201309076

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