The noodle defense

Macrophages ingest and kill microbes by phagocytosis and delivery to lysosomes. In this issue, Prashar et al. (2013, J. Cell Biol. http://dx.doi.org/10.1083/jcb.201304095) demonstrate that the elongated morphology of filamentous bacteria does not prevent ingestion by macrophages or the fusion of lys...

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Detalles Bibliográficos
Autor principal: Swanson, Joel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871438/
https://www.ncbi.nlm.nih.gov/pubmed/24368803
http://dx.doi.org/10.1083/jcb.201310128
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author Swanson, Joel A.
author_facet Swanson, Joel A.
author_sort Swanson, Joel A.
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description Macrophages ingest and kill microbes by phagocytosis and delivery to lysosomes. In this issue, Prashar et al. (2013, J. Cell Biol. http://dx.doi.org/10.1083/jcb.201304095) demonstrate that the elongated morphology of filamentous bacteria does not prevent ingestion by macrophages or the fusion of lysosomes, but creates a chimeric, unclosed phagolysosomal compartment whose leakiness blunts the toxicity of lysosomal enzymes, thereby increasing bacterial survival.
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spelling pubmed-38714382014-06-23 The noodle defense Swanson, Joel A. J Cell Biol Reviews Macrophages ingest and kill microbes by phagocytosis and delivery to lysosomes. In this issue, Prashar et al. (2013, J. Cell Biol. http://dx.doi.org/10.1083/jcb.201304095) demonstrate that the elongated morphology of filamentous bacteria does not prevent ingestion by macrophages or the fusion of lysosomes, but creates a chimeric, unclosed phagolysosomal compartment whose leakiness blunts the toxicity of lysosomal enzymes, thereby increasing bacterial survival. The Rockefeller University Press 2013-12-23 /pmc/articles/PMC3871438/ /pubmed/24368803 http://dx.doi.org/10.1083/jcb.201310128 Text en © 2013 Swanson This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Swanson, Joel A.
The noodle defense
title The noodle defense
title_full The noodle defense
title_fullStr The noodle defense
title_full_unstemmed The noodle defense
title_short The noodle defense
title_sort noodle defense
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871438/
https://www.ncbi.nlm.nih.gov/pubmed/24368803
http://dx.doi.org/10.1083/jcb.201310128
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