Posttranslational regulation of tissue inhibitor of metalloproteinase-1 by calcium-dependent vesicular exocytosis

Liver myofibroblasts derived from hepatic stellate cells (HSC) are critical mediators of liver fibrosis. Release of tissue inhibitor of metalloproteinase-1 (TIMP-1) advances liver fibrosis by blocking fibrinolysis. The mechanisms responsible for the posttranslational regulation of TIMP-1 by myofibro...

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Autores principales: Dranoff, Jonathan A, Bhatia, Neal, Fausther, Michel, Lavoie, Elise G, Granell, Susana, Baldini, Giulia, Hickman, DaShawn A, Sheung, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871447/
https://www.ncbi.nlm.nih.gov/pubmed/24400134
http://dx.doi.org/10.1002/phy2.125
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author Dranoff, Jonathan A
Bhatia, Neal
Fausther, Michel
Lavoie, Elise G
Granell, Susana
Baldini, Giulia
Hickman, DaShawn A
Sheung, Nina
author_facet Dranoff, Jonathan A
Bhatia, Neal
Fausther, Michel
Lavoie, Elise G
Granell, Susana
Baldini, Giulia
Hickman, DaShawn A
Sheung, Nina
author_sort Dranoff, Jonathan A
collection PubMed
description Liver myofibroblasts derived from hepatic stellate cells (HSC) are critical mediators of liver fibrosis. Release of tissue inhibitor of metalloproteinase-1 (TIMP-1) advances liver fibrosis by blocking fibrinolysis. The mechanisms responsible for the posttranslational regulation of TIMP-1 by myofibroblastic HSC are unknown. Here, we demonstrate that TIMP-1 release by HSC is regulated in a posttranslational fashion via calcium-sensitive vesicular exocytosis. To our knowledge, this is the first article to directly examine vesicular trafficking in myofibroblastic HSC, potentially providing a new target to treat and or prevent liver fibrosis.
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spelling pubmed-38714472014-01-07 Posttranslational regulation of tissue inhibitor of metalloproteinase-1 by calcium-dependent vesicular exocytosis Dranoff, Jonathan A Bhatia, Neal Fausther, Michel Lavoie, Elise G Granell, Susana Baldini, Giulia Hickman, DaShawn A Sheung, Nina Physiol Rep Original Research Liver myofibroblasts derived from hepatic stellate cells (HSC) are critical mediators of liver fibrosis. Release of tissue inhibitor of metalloproteinase-1 (TIMP-1) advances liver fibrosis by blocking fibrinolysis. The mechanisms responsible for the posttranslational regulation of TIMP-1 by myofibroblastic HSC are unknown. Here, we demonstrate that TIMP-1 release by HSC is regulated in a posttranslational fashion via calcium-sensitive vesicular exocytosis. To our knowledge, this is the first article to directly examine vesicular trafficking in myofibroblastic HSC, potentially providing a new target to treat and or prevent liver fibrosis. Blackwell Publishing Ltd 2013-11 2013-10-31 /pmc/articles/PMC3871447/ /pubmed/24400134 http://dx.doi.org/10.1002/phy2.125 Text en © 2013 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Original Research
Dranoff, Jonathan A
Bhatia, Neal
Fausther, Michel
Lavoie, Elise G
Granell, Susana
Baldini, Giulia
Hickman, DaShawn A
Sheung, Nina
Posttranslational regulation of tissue inhibitor of metalloproteinase-1 by calcium-dependent vesicular exocytosis
title Posttranslational regulation of tissue inhibitor of metalloproteinase-1 by calcium-dependent vesicular exocytosis
title_full Posttranslational regulation of tissue inhibitor of metalloproteinase-1 by calcium-dependent vesicular exocytosis
title_fullStr Posttranslational regulation of tissue inhibitor of metalloproteinase-1 by calcium-dependent vesicular exocytosis
title_full_unstemmed Posttranslational regulation of tissue inhibitor of metalloproteinase-1 by calcium-dependent vesicular exocytosis
title_short Posttranslational regulation of tissue inhibitor of metalloproteinase-1 by calcium-dependent vesicular exocytosis
title_sort posttranslational regulation of tissue inhibitor of metalloproteinase-1 by calcium-dependent vesicular exocytosis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871447/
https://www.ncbi.nlm.nih.gov/pubmed/24400134
http://dx.doi.org/10.1002/phy2.125
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