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Effects of hyperbaric oxygen preconditioning on cardiac stress markers after simulated diving

Hyperbaric oxygen preconditioning (HBO-PC) can protect the heart from injury during subsequent ischemia. The presence of high loads of venous gas emboli (VGE) induced by a rapid ambient pressure reduction on ascent from diving may cause ischemia and acute heart failure. The aim of this study was to...

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Autores principales: Jørgensen, Arve, Foster, Philip P, Brubakk, Alf O, Eftedal, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871481/
https://www.ncbi.nlm.nih.gov/pubmed/24400168
http://dx.doi.org/10.1002/phy2.169
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author Jørgensen, Arve
Foster, Philip P
Brubakk, Alf O
Eftedal, Ingrid
author_facet Jørgensen, Arve
Foster, Philip P
Brubakk, Alf O
Eftedal, Ingrid
author_sort Jørgensen, Arve
collection PubMed
description Hyperbaric oxygen preconditioning (HBO-PC) can protect the heart from injury during subsequent ischemia. The presence of high loads of venous gas emboli (VGE) induced by a rapid ambient pressure reduction on ascent from diving may cause ischemia and acute heart failure. The aim of this study was to investigate the effect of diving-induced VGE formation on cardiac stress marker levels and the cardioprotective effect of HBO-PC. To induce high loads of VGE, 63 female Sprague–Dawley rats were subjected to a rapid ambient pressure reduction from a simulated saturation dive (50 min at 709 kPa) in a pressure chamber. VGE loads were measured for 60 min in anesthetized animals by the use of ultrasonography. The animals were divided into five groups. Three groups were exposed to either diving or to HBO-PC (100% oxygen, 38 min at 303 kPa) with a 45 or 180 min interval between HBO-PC and diving. Two additional groups were used as baseline controls for the measurements; one group was exposed to equal handling except for HBO-PC and diving, and the other group was completely unexposed. Diving caused high loads of VGE, as well as elevated levels of the cardiac stress markers, cardiac troponin T (cTnT), natriuretic peptide precursor B (Nppb), and αB-crystallin, in blood and cardiac tissue. There were strong positive correlations between VGE loads and stress marker levels after diving, and HBO-PC appeared to have a cardioprotective effect, as indicated by the lower levels of stress marker expression after diving-induced VGE formation.
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spelling pubmed-38714812014-01-07 Effects of hyperbaric oxygen preconditioning on cardiac stress markers after simulated diving Jørgensen, Arve Foster, Philip P Brubakk, Alf O Eftedal, Ingrid Physiol Rep Original Research Hyperbaric oxygen preconditioning (HBO-PC) can protect the heart from injury during subsequent ischemia. The presence of high loads of venous gas emboli (VGE) induced by a rapid ambient pressure reduction on ascent from diving may cause ischemia and acute heart failure. The aim of this study was to investigate the effect of diving-induced VGE formation on cardiac stress marker levels and the cardioprotective effect of HBO-PC. To induce high loads of VGE, 63 female Sprague–Dawley rats were subjected to a rapid ambient pressure reduction from a simulated saturation dive (50 min at 709 kPa) in a pressure chamber. VGE loads were measured for 60 min in anesthetized animals by the use of ultrasonography. The animals were divided into five groups. Three groups were exposed to either diving or to HBO-PC (100% oxygen, 38 min at 303 kPa) with a 45 or 180 min interval between HBO-PC and diving. Two additional groups were used as baseline controls for the measurements; one group was exposed to equal handling except for HBO-PC and diving, and the other group was completely unexposed. Diving caused high loads of VGE, as well as elevated levels of the cardiac stress markers, cardiac troponin T (cTnT), natriuretic peptide precursor B (Nppb), and αB-crystallin, in blood and cardiac tissue. There were strong positive correlations between VGE loads and stress marker levels after diving, and HBO-PC appeared to have a cardioprotective effect, as indicated by the lower levels of stress marker expression after diving-induced VGE formation. Blackwell Publishing Ltd 2013-11 2013-11-24 /pmc/articles/PMC3871481/ /pubmed/24400168 http://dx.doi.org/10.1002/phy2.169 Text en © 2013 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Original Research
Jørgensen, Arve
Foster, Philip P
Brubakk, Alf O
Eftedal, Ingrid
Effects of hyperbaric oxygen preconditioning on cardiac stress markers after simulated diving
title Effects of hyperbaric oxygen preconditioning on cardiac stress markers after simulated diving
title_full Effects of hyperbaric oxygen preconditioning on cardiac stress markers after simulated diving
title_fullStr Effects of hyperbaric oxygen preconditioning on cardiac stress markers after simulated diving
title_full_unstemmed Effects of hyperbaric oxygen preconditioning on cardiac stress markers after simulated diving
title_short Effects of hyperbaric oxygen preconditioning on cardiac stress markers after simulated diving
title_sort effects of hyperbaric oxygen preconditioning on cardiac stress markers after simulated diving
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871481/
https://www.ncbi.nlm.nih.gov/pubmed/24400168
http://dx.doi.org/10.1002/phy2.169
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