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Aberrant Interference of Auditory Negative Words on Attention in Patients with Schizophrenia

Previous research suggests that deficits in attention-emotion interaction are implicated in schizophrenia symptoms. Although disruption in auditory processing is crucial in the pathophysiology of schizophrenia, deficits in interaction between emotional processing of auditorily presented language sti...

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Autores principales: Iwashiro, Norichika, Yahata, Noriaki, Kawamuro, Yu, Kasai, Kiyoto, Yamasue, Hidenori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871545/
https://www.ncbi.nlm.nih.gov/pubmed/24376662
http://dx.doi.org/10.1371/journal.pone.0083201
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author Iwashiro, Norichika
Yahata, Noriaki
Kawamuro, Yu
Kasai, Kiyoto
Yamasue, Hidenori
author_facet Iwashiro, Norichika
Yahata, Noriaki
Kawamuro, Yu
Kasai, Kiyoto
Yamasue, Hidenori
author_sort Iwashiro, Norichika
collection PubMed
description Previous research suggests that deficits in attention-emotion interaction are implicated in schizophrenia symptoms. Although disruption in auditory processing is crucial in the pathophysiology of schizophrenia, deficits in interaction between emotional processing of auditorily presented language stimuli and auditory attention have not yet been clarified. To address this issue, the current study used a dichotic listening task to examine 22 patients with schizophrenia and 24 age-, sex-, parental socioeconomic background-, handedness-, dexterous ear-, and intelligence quotient-matched healthy controls. The participants completed a word recognition task on the attended side in which a word with emotionally valenced content (negative/positive/neutral) was presented to one ear and a different neutral word was presented to the other ear. Participants selectively attended to either ear. In the control subjects, presentation of negative but not positive word stimuli provoked a significantly prolonged reaction time compared with presentation of neutral word stimuli. This interference effect for negative words existed whether or not subjects directed attention to the negative words. This interference effect was significantly smaller in the patients with schizophrenia than in the healthy controls. Furthermore, the smaller interference effect was significantly correlated with severe positive symptoms and delusional behavior in the patients with schizophrenia. The present findings suggest that aberrant interaction between semantic processing of negative emotional content and auditory attention plays a role in production of positive symptoms in schizophrenia. (224 words)
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spelling pubmed-38715452013-12-27 Aberrant Interference of Auditory Negative Words on Attention in Patients with Schizophrenia Iwashiro, Norichika Yahata, Noriaki Kawamuro, Yu Kasai, Kiyoto Yamasue, Hidenori PLoS One Research Article Previous research suggests that deficits in attention-emotion interaction are implicated in schizophrenia symptoms. Although disruption in auditory processing is crucial in the pathophysiology of schizophrenia, deficits in interaction between emotional processing of auditorily presented language stimuli and auditory attention have not yet been clarified. To address this issue, the current study used a dichotic listening task to examine 22 patients with schizophrenia and 24 age-, sex-, parental socioeconomic background-, handedness-, dexterous ear-, and intelligence quotient-matched healthy controls. The participants completed a word recognition task on the attended side in which a word with emotionally valenced content (negative/positive/neutral) was presented to one ear and a different neutral word was presented to the other ear. Participants selectively attended to either ear. In the control subjects, presentation of negative but not positive word stimuli provoked a significantly prolonged reaction time compared with presentation of neutral word stimuli. This interference effect for negative words existed whether or not subjects directed attention to the negative words. This interference effect was significantly smaller in the patients with schizophrenia than in the healthy controls. Furthermore, the smaller interference effect was significantly correlated with severe positive symptoms and delusional behavior in the patients with schizophrenia. The present findings suggest that aberrant interaction between semantic processing of negative emotional content and auditory attention plays a role in production of positive symptoms in schizophrenia. (224 words) Public Library of Science 2013-12-23 /pmc/articles/PMC3871545/ /pubmed/24376662 http://dx.doi.org/10.1371/journal.pone.0083201 Text en © 2013 Iwashiro et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Iwashiro, Norichika
Yahata, Noriaki
Kawamuro, Yu
Kasai, Kiyoto
Yamasue, Hidenori
Aberrant Interference of Auditory Negative Words on Attention in Patients with Schizophrenia
title Aberrant Interference of Auditory Negative Words on Attention in Patients with Schizophrenia
title_full Aberrant Interference of Auditory Negative Words on Attention in Patients with Schizophrenia
title_fullStr Aberrant Interference of Auditory Negative Words on Attention in Patients with Schizophrenia
title_full_unstemmed Aberrant Interference of Auditory Negative Words on Attention in Patients with Schizophrenia
title_short Aberrant Interference of Auditory Negative Words on Attention in Patients with Schizophrenia
title_sort aberrant interference of auditory negative words on attention in patients with schizophrenia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871545/
https://www.ncbi.nlm.nih.gov/pubmed/24376662
http://dx.doi.org/10.1371/journal.pone.0083201
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