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MMP Mediated Degradation of Type IV Collagen Alpha 1 and Alpha 3 Chains Reflects Basement Membrane Remodeling in Experimental and Clinical Fibrosis – Validation of Two Novel Biomarker Assays
OBJECTIVES: Fibrosis is characterized by excessive tissue remodeling resulting from altered expression of various growth factors, cytokines and proteases. We hypothesized that matrix metalloproteinase (MMP) mediated degradation of type IV collagen, a main component of the basement membrane, will rel...
Autores principales: | Sand, Jannie Marie, Larsen, Lise, Hogaboam, Cory, Martinez, Fernando, Han, MeiLan, Røssel Larsen, Martin, Nawrocki, Arkadiusz, Zheng, Qinlong, Asser Karsdal, Morten, Leeming, Diana Julie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871599/ https://www.ncbi.nlm.nih.gov/pubmed/24376856 http://dx.doi.org/10.1371/journal.pone.0084934 |
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