Cargando…

Effects of Inhibition of Serine Palmitoyltransferase (SPT) and Sphingosine Kinase 1 (SphK1) on Palmitate Induced Insulin Resistance in L6 Myotubes

BACKGROUND: The objective of this study was to examine the effects of short (2 h) and prolonged (18 h) inhibition of serine palmitoyltransferase (SPT) and sphingosine kinase 1 (SphK1) on palmitate (PA) induced insulin resistance in L6 myotubes. METHODS: L6 myotubes were treated simultaneously with e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mikłosz, Agnieszka, Łukaszuk, Bartłomiej, Baranowski, Marcin, Górski, Jan, Chabowski, Adrian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871603/ https://www.ncbi.nlm.nih.gov/pubmed/24376889 http://dx.doi.org/10.1371/journal.pone.0085547

Ejemplares similares

Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget
por: Hatoum, Diana, et al.
Publicado: (2017)

Challenging of AS160/TBC1D4 Alters Intracellular Lipid milieu in L6 Myotubes Incubated With Palmitate
por: Mikłosz, Agnieszka, et al.
Publicado: (2017)

Sphingosine Kinase-1 (SphK-1) Regulates Mycobacterium smegmatis Infection in Macrophages
por: Prakash, Hridayesh, et al.
Publicado: (2010)

Dose‐ and time‐dependent alterations in lipid metabolism after pharmacological PGC‐1α activation in L6 myotubes
por: Supruniuk, Elżbieta, et al.
Publicado: (2018)

Assessment of the Main Compounds of the Lipolytic System in Treadmill Running Rats: Different Response Patterns between the Right and Left Ventricle
por: Mikłosz, Agnieszka, et al.
Publicado: (2019)

Therapeutic Potential of SphK1 Inhibitors Based on Abnormal Expression of SphK1 in Inflammatory Immune Related-Diseases
por: Bu, Yanhong, et al.
Publicado: (2021)

Identification of sphingosine kinase 1 (SphK1) as a primary target of icaritin in hepatocellular carcinoma cells
por: Lu, Pei-Hua, et al.
Publicado: (2017)

Pyrroloquinoline Quinone Modifies Lipid Profile, but Not Insulin Sensitivity, of Palmitic Acid-Treated L6 Myotubes
por: Supruniuk, Elżbieta, et al.
Publicado: (2020)

Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR/SphK1 crosstalk
por: Schiefler, Carlotta, et al.
Publicado: (2014)

Triple Negative Breast Cancer Depends on Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P)/Sphingosine 1-Phosphate Receptor 3 (S1PR3)/Notch Signaling for Metastasis
por: Wang, Shushu, et al.
Publicado: (2018)

Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells
por: Bazzazi, Hojjat, et al.
Publicado: (2017)

Treadmill Running Changes Endothelial Lipase Expression: Insights from Gene and Protein Analysis in Various Striated Muscle Tissues and Serum
por: Mikłosz, Agnieszka, et al.
Publicado: (2021)

Aerobic Training in Rats Increases Skeletal Muscle Sphingomyelinase and Serine Palmitoyltransferase Activity, While Decreasing Ceramidase Activity
por: Błachnio-Zabielska, Agnieszka, et al.
Publicado: (2010)

Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo
por: Xun, Cai, et al.
Publicado: (2015)

Activation of SphK1 by adipocytes mediates epithelial ovarian cancer cell proliferation
por: Dai, Lan, et al.
Publicado: (2021)

SphK2 over-expression promotes osteosarcoma cell growth
por: Xu, Dawei, et al.
Publicado: (2017)

Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1
por: Vettorazzi, Sabine, et al.
Publicado: (2015)

The therapeutic value of the SphK1-targeting microRNA-3677 in human osteosarcoma cells
por: Yao, Chen, et al.
Publicado: (2020)

Targeting SphK1/2 by SKI-178 inhibits prostate cancer cell growth
por: Jin, Lu, et al.
Publicado: (2023)

Ceramide and Sphingosine Regulation of Myelinogenesis: Targeting Serine Palmitoyltransferase Using microRNA in Multiple Sclerosis
por: Dasgupta, Somsankar, et al.
Publicado: (2019)

Targeting SphK2 Reverses Acquired Resistance of Regorafenib in Hepatocellular Carcinoma
por: Shi, Weiwei, et al.
Publicado: (2020)

Activation of SphK2 contributes to adipocyte-induced EOC cell proliferation
por: Dai, Lan, et al.
Publicado: (2022)

Dabigatran Suppresses PAR-1/SphK/S1P Activation of Astrocytes in Experimental Autoimmune Encephalomyelitis Model
por: Chen, Rong, et al.
Publicado: (2020)

MiR-124 inhibits the migration and invasion of ovarian cancer cells by targeting SphK1
por: Zhang, Hanwen, et al.
Publicado: (2013)

Activation of the SphK1/ERK/p-ERK pathway promotes autophagy in colon cancer cells
por: Xu, Chunyan, et al.
Publicado: (2018)

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease
por: Lee, Ju Youn, et al.
Publicado: (2018)

Targeting the SphK-S1P-SIPR Pathway as a Potential Therapeutic Approach for COVID-19
por: McGowan, Eileen M, et al.
Publicado: (2020)

SphK1‐driven autophagy potentiates focal adhesion paxillin‐mediated metastasis in colorectal cancer
por: Wu, Jiang‐Ni, et al.
Publicado: (2021)

Cloning, expression and characterization of serine palmitoyltransferase (SPT)-like gene subunit (LCB2) from marine Emiliania huxleyi virus (Coccolithovirus)
por: Liu, Xuhong, et al.
Publicado: (2012)

Pathological roles of the VEGF/SphK pathway in Niemann–Pick type C neurons
por: Lee, Hyun, et al.
Publicado: (2014)

Inhibition of Ceramide De Novo Synthesis Ameliorates Diet Induced Skeletal Muscles Insulin Resistance
por: Kurek, Krzysztof, et al.
Publicado: (2015)

Changes in the Diaphragm Lipid Content after Administration of Streptozotocin and High-Fat Diet Regime
por: Lukaszuk, Bartlomiej, et al.
Publicado: (2017)

SphK1-targeted miR-6784 inhibits functions of skin squamous cell carcinoma cells
por: Gong, Zhen-Hua, et al.
Publicado: (2021)

Does TBC1D4 (AS160) or TBC1D1 Deficiency Affect the Expression of Fatty Acid Handling Proteins in the Adipocytes Differentiated from Human Adipose-Derived Mesenchymal Stem Cells (ADMSCs) Obtained from Subcutaneous and Visceral Fat Depots?
por: Mikłosz, Agnieszka, et al.
Publicado: (2021)

Multivessel Coronary Artery Disease Complicated by Diabetes Mellitus Has a Relatively Small Effect on Endothelial and Lipoprotein Lipases Expression in the Human Atrial Myocardium and Coronary Perivascular Adipose Tissue
por: Knapp, Małgorzata, et al.
Publicado: (2023)

Inhibition of SphK1/S1P Signaling Pathway Alleviates Fibrosis and Inflammation of Rat Myocardium after Myocardial Infarction
por: Wu, Xiaokui, et al.
Publicado: (2022)

SphK-produced S1P in somatic cells is indispensable for LH-EGFR signaling-induced mouse oocyte maturation
por: Yuan, Feifei, et al.
Publicado: (2022)

RabGAP AS160/TBC1D4 deficiency increases long-chain fatty acid transport but has little additional effect on obesity and metabolic syndrome in ADMSCs-derived adipocytes of morbidly obese women
por: Mikłosz, Agnieszka, et al.
Publicado: (2023)

β-Caryophyllene from Chilli Pepper Inhibits the Proliferation of Non-Small Cell Lung Cancer Cells by Affecting miR-659-3p-Targeted Sphingosine Kinase 1 (SphK1)
por: Lei, Jiaji, et al.
Publicado: (2021)

An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma
por: Pan, Jian, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_vrncmi5asl7fsq5ntkmuf67p2e