Antibody-Mediated Targeting of the Orai1 Calcium Channel Inhibits T Cell Function

Despite the attractiveness of ion channels as therapeutic targets, there are no examples of monoclonal antibodies directed against ion channels in clinical development. Antibody-mediated inhibition of ion channels could offer a directed, specific therapeutic approach. To investigate the potential of...

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Detalles Bibliográficos
Autores principales: Cox, Jennifer H., Hussell, Scott, Søndergaard, Henrik, Roepstorff, Kirstine, Bui, John-Vu, Deer, Jen Running, Zhang, Jun, Li, Zhan-Guo, Lamberth, Kasper, Kvist, Peter Helding, Padkjær, Søren, Haase, Claus, Zahn, Stefan, Odegard, Valerie H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871607/
https://www.ncbi.nlm.nih.gov/pubmed/24376610
http://dx.doi.org/10.1371/journal.pone.0082944

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