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Long-term quercetin supplementation reduces lipid peroxidation but does not improve performance in endurance runners

PURPOSE: To evaluate the effects of chronic quercetin supplementation on endurance performance and antioxidant status in long distance runners. We hypothesized that an improved antioxidant status can be associated with enhanced performance. METHODS: During 6 weeks of supplementation utilizing a doub...

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Autores principales: Scholten, Shane D, Sergeev, Igor N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871649/
https://www.ncbi.nlm.nih.gov/pubmed/24379709
http://dx.doi.org/10.2147/OAJSM.S39632
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author Scholten, Shane D
Sergeev, Igor N
author_facet Scholten, Shane D
Sergeev, Igor N
author_sort Scholten, Shane D
collection PubMed
description PURPOSE: To evaluate the effects of chronic quercetin supplementation on endurance performance and antioxidant status in long distance runners. We hypothesized that an improved antioxidant status can be associated with enhanced performance. METHODS: During 6 weeks of supplementation utilizing a double blind, randomized design, young male subjects received quercetin (1000 mg/day) or placebo while maintaining their current training schedules. RESULTS: Following the end of the supplementation period, there was a significant time × supplement interaction for serum malondialdehyde (MDA), an indicator of lipid peroxidation. There were no significant pre- to post-supplement changes in parameter values employed for measuring total antioxidant capacity, superoxide dismutase activity, and protein oxidation (protein carbonyl) in serum. There were also no significant pre- to post-supplement differences in VO(2peak), running economy, heart rate, and rating of perceived exertion (RPE) during the 10 km time trial. CONCLUSION: The findings obtained indicate that there is a relationship between quercetin supplementation and the statistically significant decreasing trend in MDA levels following 6 weeks of supplementation and training. This evidence suggests that quercetin can reduce oxidative stress (lipid peroxidation). However, performance improvements were not significant (as measured by VO(2peak), running economy, heart rate, and RPE).
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spelling pubmed-38716492013-12-30 Long-term quercetin supplementation reduces lipid peroxidation but does not improve performance in endurance runners Scholten, Shane D Sergeev, Igor N Open Access J Sports Med Original Research PURPOSE: To evaluate the effects of chronic quercetin supplementation on endurance performance and antioxidant status in long distance runners. We hypothesized that an improved antioxidant status can be associated with enhanced performance. METHODS: During 6 weeks of supplementation utilizing a double blind, randomized design, young male subjects received quercetin (1000 mg/day) or placebo while maintaining their current training schedules. RESULTS: Following the end of the supplementation period, there was a significant time × supplement interaction for serum malondialdehyde (MDA), an indicator of lipid peroxidation. There were no significant pre- to post-supplement changes in parameter values employed for measuring total antioxidant capacity, superoxide dismutase activity, and protein oxidation (protein carbonyl) in serum. There were also no significant pre- to post-supplement differences in VO(2peak), running economy, heart rate, and rating of perceived exertion (RPE) during the 10 km time trial. CONCLUSION: The findings obtained indicate that there is a relationship between quercetin supplementation and the statistically significant decreasing trend in MDA levels following 6 weeks of supplementation and training. This evidence suggests that quercetin can reduce oxidative stress (lipid peroxidation). However, performance improvements were not significant (as measured by VO(2peak), running economy, heart rate, and RPE). Dove Medical Press 2013-03-12 /pmc/articles/PMC3871649/ /pubmed/24379709 http://dx.doi.org/10.2147/OAJSM.S39632 Text en © 2013 Scholten and Sergeev, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Scholten, Shane D
Sergeev, Igor N
Long-term quercetin supplementation reduces lipid peroxidation but does not improve performance in endurance runners
title Long-term quercetin supplementation reduces lipid peroxidation but does not improve performance in endurance runners
title_full Long-term quercetin supplementation reduces lipid peroxidation but does not improve performance in endurance runners
title_fullStr Long-term quercetin supplementation reduces lipid peroxidation but does not improve performance in endurance runners
title_full_unstemmed Long-term quercetin supplementation reduces lipid peroxidation but does not improve performance in endurance runners
title_short Long-term quercetin supplementation reduces lipid peroxidation but does not improve performance in endurance runners
title_sort long-term quercetin supplementation reduces lipid peroxidation but does not improve performance in endurance runners
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871649/
https://www.ncbi.nlm.nih.gov/pubmed/24379709
http://dx.doi.org/10.2147/OAJSM.S39632
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