Targeting CD28, CTLA-4 and PD-L1 Costimulation Differentially Controls Immune Synapses and Function of Human Regulatory and Conventional T-Cells

CD28, CTLA-4 and PD-L1, the three identified ligands for CD80/86, are pivotal positive and negative costimulatory molecules that, among other functions, control T cell motility and formation of immune synapse between T cells and antigen-presenting cells (APCs). What remains incompletely understood i...

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Detalles Bibliográficos
Autores principales: Dilek, Nahzli, Poirier, Nicolas, Hulin, Philippe, Coulon, Flora, Mary, Caroline, Ville, Simon, Vie, Henri, Clémenceau, Béatrice, Blancho, Gilles, Vanhove, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871694/
https://www.ncbi.nlm.nih.gov/pubmed/24376655
http://dx.doi.org/10.1371/journal.pone.0083139

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