Exome Sequencing Identifies Early Gastric Carcinoma as an Early Stage of Advanced Gastric Cancer

Gastric carcinoma is one of the major causes of cancer-related mortality worldwide. Early detection and treatment leads to an excellent prognosis in patients with early gastric cancer (EGC), whereas the prognosis of patients with advanced gastric cancer (AGC) remains poor. It is unclear whether EGCs...

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Detalles Bibliográficos
Autores principales: Kang, Guhyun, Hwang, Woo Cheol, Do, In-Gu, Wang, Kai, Kang, So Young, Lee, Jeeyun, Park, Se Hoon, Park, Joon Oh, Kang, Won Ki, Jang, Jiryeon, Choi, Min-Gew, Lee, Jun Ho, Sohn, Tae Sung, Bae, Jae Moon, Kim, Sung, Kim, Min Ji, Kim, Seonwoo, Park, Cheol Keun, Kim, Kyoung-Mee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871845/
https://www.ncbi.nlm.nih.gov/pubmed/24376576
http://dx.doi.org/10.1371/journal.pone.0082770
Descripción
Sumario:Gastric carcinoma is one of the major causes of cancer-related mortality worldwide. Early detection and treatment leads to an excellent prognosis in patients with early gastric cancer (EGC), whereas the prognosis of patients with advanced gastric cancer (AGC) remains poor. It is unclear whether EGCs and AGCs are distinct entities or whether EGCs are the beginning stages of AGCs. We performed whole exome sequencing of four samples from patients with EGC and compared the results with those from AGCs. In both EGCs and AGCs, a total of 268 genes were commonly mutated and independent mutations were additionally found in EGCs (516 genes) and AGCs (3104 genes). A higher frequency of C>G transitions was observed in intestinal-type compared to diffuse-type carcinomas (P = 0.010). The DYRK3, GPR116, MCM10, PCDH17, PCDHB1, RDH5 and UNC5C genes are recurrently mutated in EGCs and may be involved in early carcinogenesis.

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