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What We Have Learned about Autism Spectrum Disorder from Valproic Acid
Two recent epidemiological investigations in children exposed to valproic acid (VPA) treatment in utero have reported a significant risk associated with neurodevelopmental disorders and autism spectrum disorder (ASD) in particular. Parallel to this work, there is a growing body of animal research li...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871912/ https://www.ncbi.nlm.nih.gov/pubmed/24381784 http://dx.doi.org/10.1155/2013/712758 |
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author | Chomiak, Taylor Turner, Nathanael Hu, Bin |
author_facet | Chomiak, Taylor Turner, Nathanael Hu, Bin |
author_sort | Chomiak, Taylor |
collection | PubMed |
description | Two recent epidemiological investigations in children exposed to valproic acid (VPA) treatment in utero have reported a significant risk associated with neurodevelopmental disorders and autism spectrum disorder (ASD) in particular. Parallel to this work, there is a growing body of animal research literature using VPA as an animal model of ASD. In this focused review we first summarize the epidemiological evidence linking VPA to ASD and then comment on two important neurobiological findings linking VPA to ASD clinicopathology, namely, accelerated or early brain overgrowth and hyperexcitable networks. Improving our understanding of how the drug VPA can alter early development of neurological systems will ultimately improve our understanding of ASD. |
format | Online Article Text |
id | pubmed-3871912 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38719122013-12-31 What We Have Learned about Autism Spectrum Disorder from Valproic Acid Chomiak, Taylor Turner, Nathanael Hu, Bin Patholog Res Int Review Article Two recent epidemiological investigations in children exposed to valproic acid (VPA) treatment in utero have reported a significant risk associated with neurodevelopmental disorders and autism spectrum disorder (ASD) in particular. Parallel to this work, there is a growing body of animal research literature using VPA as an animal model of ASD. In this focused review we first summarize the epidemiological evidence linking VPA to ASD and then comment on two important neurobiological findings linking VPA to ASD clinicopathology, namely, accelerated or early brain overgrowth and hyperexcitable networks. Improving our understanding of how the drug VPA can alter early development of neurological systems will ultimately improve our understanding of ASD. Hindawi Publishing Corporation 2013 2013-12-17 /pmc/articles/PMC3871912/ /pubmed/24381784 http://dx.doi.org/10.1155/2013/712758 Text en Copyright © 2013 Taylor Chomiak et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Chomiak, Taylor Turner, Nathanael Hu, Bin What We Have Learned about Autism Spectrum Disorder from Valproic Acid |
title | What We Have Learned about Autism Spectrum Disorder from Valproic Acid |
title_full | What We Have Learned about Autism Spectrum Disorder from Valproic Acid |
title_fullStr | What We Have Learned about Autism Spectrum Disorder from Valproic Acid |
title_full_unstemmed | What We Have Learned about Autism Spectrum Disorder from Valproic Acid |
title_short | What We Have Learned about Autism Spectrum Disorder from Valproic Acid |
title_sort | what we have learned about autism spectrum disorder from valproic acid |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871912/ https://www.ncbi.nlm.nih.gov/pubmed/24381784 http://dx.doi.org/10.1155/2013/712758 |
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