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New roles for “old” microRNAs in nervous system function and disease
Since their discovery, microRNAs became prominent candidates providing missing links on how to explain the developmental and phenotypical variation within one species or among different species. In addition, microRNAs were implicated in diseases such as neurodegeneration and cancer. More recently, t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871958/ https://www.ncbi.nlm.nih.gov/pubmed/24399929 http://dx.doi.org/10.3389/fnmol.2013.00051 |
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author | Hartl, Marion Grunwald Kadow, Ilona C. |
author_facet | Hartl, Marion Grunwald Kadow, Ilona C. |
author_sort | Hartl, Marion |
collection | PubMed |
description | Since their discovery, microRNAs became prominent candidates providing missing links on how to explain the developmental and phenotypical variation within one species or among different species. In addition, microRNAs were implicated in diseases such as neurodegeneration and cancer. More recently, the regulation of animal behavior was shown to be influenced by microRNAs. In spite of their numerous functions, only a few microRNAs were discovered by using classic genetic approaches. Due to the very mild or redundant phenotypes of most microRNAs or their genomic location within introns of other genes many regulatory microRNAs were missed. In this review, we focus on three microRNAs first identified in a forward genetic screen in invertebrates for their essential function in animal development, namely bantam, let-7, and miR-279. All three are essential for survival, are not located in introns of other genes, and are highly conserved among species. We highlight their important functions in the nervous system and discuss their emerging roles, especially during nervous system disease and behavior. |
format | Online Article Text |
id | pubmed-3871958 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-38719582014-01-07 New roles for “old” microRNAs in nervous system function and disease Hartl, Marion Grunwald Kadow, Ilona C. Front Mol Neurosci Neuroscience Since their discovery, microRNAs became prominent candidates providing missing links on how to explain the developmental and phenotypical variation within one species or among different species. In addition, microRNAs were implicated in diseases such as neurodegeneration and cancer. More recently, the regulation of animal behavior was shown to be influenced by microRNAs. In spite of their numerous functions, only a few microRNAs were discovered by using classic genetic approaches. Due to the very mild or redundant phenotypes of most microRNAs or their genomic location within introns of other genes many regulatory microRNAs were missed. In this review, we focus on three microRNAs first identified in a forward genetic screen in invertebrates for their essential function in animal development, namely bantam, let-7, and miR-279. All three are essential for survival, are not located in introns of other genes, and are highly conserved among species. We highlight their important functions in the nervous system and discuss their emerging roles, especially during nervous system disease and behavior. Frontiers Media S.A. 2013-12-24 /pmc/articles/PMC3871958/ /pubmed/24399929 http://dx.doi.org/10.3389/fnmol.2013.00051 Text en Copyright © 2013 Hartl and Grunwald Kadow. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Hartl, Marion Grunwald Kadow, Ilona C. New roles for “old” microRNAs in nervous system function and disease |
title | New roles for “old” microRNAs in nervous system function and disease |
title_full | New roles for “old” microRNAs in nervous system function and disease |
title_fullStr | New roles for “old” microRNAs in nervous system function and disease |
title_full_unstemmed | New roles for “old” microRNAs in nervous system function and disease |
title_short | New roles for “old” microRNAs in nervous system function and disease |
title_sort | new roles for “old” micrornas in nervous system function and disease |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871958/ https://www.ncbi.nlm.nih.gov/pubmed/24399929 http://dx.doi.org/10.3389/fnmol.2013.00051 |
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