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Genome-wide analyses of borderline personality features

The heritability of Borderline Personality (BP) features has been established in multiple twin and family studies. Using data from the borderline subscale of the Personality Assessment Inventory (PAI-BOR) collected in two Dutch cohorts (N total=7,125), the Netherlands Twin Register (NTR) and the Net...

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Autores principales: Lubke, GH, Laurin, C, Amin, N, Hottenga, JJ, Willemsen, G, van Grootheest, G, Abdellaoui, A, Karssen, LC, Oostra, BA, van Duijn, CM, Penninx, BWJH, Boomsma, DI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872258/
https://www.ncbi.nlm.nih.gov/pubmed/23979607
http://dx.doi.org/10.1038/mp.2013.109
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author Lubke, GH
Laurin, C
Amin, N
Hottenga, JJ
Willemsen, G
van Grootheest, G
Abdellaoui, A
Karssen, LC
Oostra, BA
van Duijn, CM
Penninx, BWJH
Boomsma, DI
author_facet Lubke, GH
Laurin, C
Amin, N
Hottenga, JJ
Willemsen, G
van Grootheest, G
Abdellaoui, A
Karssen, LC
Oostra, BA
van Duijn, CM
Penninx, BWJH
Boomsma, DI
author_sort Lubke, GH
collection PubMed
description The heritability of Borderline Personality (BP) features has been established in multiple twin and family studies. Using data from the borderline subscale of the Personality Assessment Inventory (PAI-BOR) collected in two Dutch cohorts (N total=7,125), the Netherlands Twin Register (NTR) and the Netherlands Study of Depression and Anxiety (NESDA), we show that heritability of the PAI-BOR total score using genome-wide SNPs is estimated at 23%, and that the genetic variance is substantially higher in affect instability items compared to the other three subscales of the PAI-BOR (42.7% vs non-significant estimates for self-harm, negative relations, and identity problems). We present results from a first GWAS of BP features, which shows a promising signal on chromosome 5 corresponding to SERINC5, a protein involved in myelination. Reduced myelination has been suggested as possibly playing a role in the development of psychiatric disorders characterized by lack of social interaction. The signal was confirmed in a third independent Dutch cohort drawn from the Erasmus Rucphen Family study (ERF, N=1301). Our analyses were complemented by investigating the heterogeneity that was implied by the differences in genetic variance components in the four subscales of the PAI-BOR. These analyses show that the association of SNPs tagging SERINC5 differs substantially across the 24 items of the PAI-BOR. Further, using reverse regression we showed that the effects were present only in subjects with higher scores on the PAI-BOR. Taken together, these results suggest that future genome-wide analyses can benefit substantially by taking into account the phenotypic and genetic heterogeneity of BP features.
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spelling pubmed-38722582015-02-01 Genome-wide analyses of borderline personality features Lubke, GH Laurin, C Amin, N Hottenga, JJ Willemsen, G van Grootheest, G Abdellaoui, A Karssen, LC Oostra, BA van Duijn, CM Penninx, BWJH Boomsma, DI Mol Psychiatry Article The heritability of Borderline Personality (BP) features has been established in multiple twin and family studies. Using data from the borderline subscale of the Personality Assessment Inventory (PAI-BOR) collected in two Dutch cohorts (N total=7,125), the Netherlands Twin Register (NTR) and the Netherlands Study of Depression and Anxiety (NESDA), we show that heritability of the PAI-BOR total score using genome-wide SNPs is estimated at 23%, and that the genetic variance is substantially higher in affect instability items compared to the other three subscales of the PAI-BOR (42.7% vs non-significant estimates for self-harm, negative relations, and identity problems). We present results from a first GWAS of BP features, which shows a promising signal on chromosome 5 corresponding to SERINC5, a protein involved in myelination. Reduced myelination has been suggested as possibly playing a role in the development of psychiatric disorders characterized by lack of social interaction. The signal was confirmed in a third independent Dutch cohort drawn from the Erasmus Rucphen Family study (ERF, N=1301). Our analyses were complemented by investigating the heterogeneity that was implied by the differences in genetic variance components in the four subscales of the PAI-BOR. These analyses show that the association of SNPs tagging SERINC5 differs substantially across the 24 items of the PAI-BOR. Further, using reverse regression we showed that the effects were present only in subjects with higher scores on the PAI-BOR. Taken together, these results suggest that future genome-wide analyses can benefit substantially by taking into account the phenotypic and genetic heterogeneity of BP features. 2013-08-27 2014-08 /pmc/articles/PMC3872258/ /pubmed/23979607 http://dx.doi.org/10.1038/mp.2013.109 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Lubke, GH
Laurin, C
Amin, N
Hottenga, JJ
Willemsen, G
van Grootheest, G
Abdellaoui, A
Karssen, LC
Oostra, BA
van Duijn, CM
Penninx, BWJH
Boomsma, DI
Genome-wide analyses of borderline personality features
title Genome-wide analyses of borderline personality features
title_full Genome-wide analyses of borderline personality features
title_fullStr Genome-wide analyses of borderline personality features
title_full_unstemmed Genome-wide analyses of borderline personality features
title_short Genome-wide analyses of borderline personality features
title_sort genome-wide analyses of borderline personality features
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872258/
https://www.ncbi.nlm.nih.gov/pubmed/23979607
http://dx.doi.org/10.1038/mp.2013.109
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