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Differences in MEG gamma oscillatory power during performance of a prosaccade task in adolescents with FASD
Fetal alcohol spectrum disorder (FASD) is characterized by a broad range of behavioral and cognitive deficits that impact the long-term quality of life for affected individuals. However, the underlying changes in brain structure and function associated with these cognitive impairments are not well-u...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872294/ https://www.ncbi.nlm.nih.gov/pubmed/24399957 http://dx.doi.org/10.3389/fnhum.2013.00900 |
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author | Stephen, Julia M. Coffman, Brian A. Stone, David B. Kodituwakku, Piyadasa |
author_facet | Stephen, Julia M. Coffman, Brian A. Stone, David B. Kodituwakku, Piyadasa |
author_sort | Stephen, Julia M. |
collection | PubMed |
description | Fetal alcohol spectrum disorder (FASD) is characterized by a broad range of behavioral and cognitive deficits that impact the long-term quality of life for affected individuals. However, the underlying changes in brain structure and function associated with these cognitive impairments are not well-understood. Previous studies identified deficits in behavioral performance of prosaccade tasks in children with FASD. In this study, we investigated group differences in gamma oscillations during performance of a prosaccade task. We collected magnetoencephalography (MEG) data from 15 adolescents with FASD and 20 age-matched healthy controls (HC) with a mean age of 15.9 ± 0.4 years during performance of a prosaccade task. Eye movement was recorded and synchronized to the MEG data using an MEG compatible eye-tracker. The MEG data were analyzed relative to the onset of the visual saccade. Time-frequency analysis was performed using Fieldtrip with a focus on group differences in gamma-band oscillations. Following left target presentation, we identified four clusters over right frontal, right parietal, and left temporal/occipital cortex, with significantly different gamma-band (30–50 Hz) power between FASD and HC. Furthermore, visual M100 latencies described in Coffman etal. (2012) corresponded with increased gamma power over right central cortex in FASD only. Gamma-band differences were not identified for stimulus-averaged responses implying that these gamma-band differences were related to differences in saccade network functioning. These differences in gamma-band power may provide indications of atypical development of cortical networks in individuals with FASD. |
format | Online Article Text |
id | pubmed-3872294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-38722942014-01-07 Differences in MEG gamma oscillatory power during performance of a prosaccade task in adolescents with FASD Stephen, Julia M. Coffman, Brian A. Stone, David B. Kodituwakku, Piyadasa Front Hum Neurosci Neuroscience Fetal alcohol spectrum disorder (FASD) is characterized by a broad range of behavioral and cognitive deficits that impact the long-term quality of life for affected individuals. However, the underlying changes in brain structure and function associated with these cognitive impairments are not well-understood. Previous studies identified deficits in behavioral performance of prosaccade tasks in children with FASD. In this study, we investigated group differences in gamma oscillations during performance of a prosaccade task. We collected magnetoencephalography (MEG) data from 15 adolescents with FASD and 20 age-matched healthy controls (HC) with a mean age of 15.9 ± 0.4 years during performance of a prosaccade task. Eye movement was recorded and synchronized to the MEG data using an MEG compatible eye-tracker. The MEG data were analyzed relative to the onset of the visual saccade. Time-frequency analysis was performed using Fieldtrip with a focus on group differences in gamma-band oscillations. Following left target presentation, we identified four clusters over right frontal, right parietal, and left temporal/occipital cortex, with significantly different gamma-band (30–50 Hz) power between FASD and HC. Furthermore, visual M100 latencies described in Coffman etal. (2012) corresponded with increased gamma power over right central cortex in FASD only. Gamma-band differences were not identified for stimulus-averaged responses implying that these gamma-band differences were related to differences in saccade network functioning. These differences in gamma-band power may provide indications of atypical development of cortical networks in individuals with FASD. Frontiers Media S.A. 2013-12-25 /pmc/articles/PMC3872294/ /pubmed/24399957 http://dx.doi.org/10.3389/fnhum.2013.00900 Text en Copyright © 2013 Stephen, Coffman, Stone and Kodituwakku. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Stephen, Julia M. Coffman, Brian A. Stone, David B. Kodituwakku, Piyadasa Differences in MEG gamma oscillatory power during performance of a prosaccade task in adolescents with FASD |
title | Differences in MEG gamma oscillatory power during performance of a prosaccade task in adolescents with FASD |
title_full | Differences in MEG gamma oscillatory power during performance of a prosaccade task in adolescents with FASD |
title_fullStr | Differences in MEG gamma oscillatory power during performance of a prosaccade task in adolescents with FASD |
title_full_unstemmed | Differences in MEG gamma oscillatory power during performance of a prosaccade task in adolescents with FASD |
title_short | Differences in MEG gamma oscillatory power during performance of a prosaccade task in adolescents with FASD |
title_sort | differences in meg gamma oscillatory power during performance of a prosaccade task in adolescents with fasd |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872294/ https://www.ncbi.nlm.nih.gov/pubmed/24399957 http://dx.doi.org/10.3389/fnhum.2013.00900 |
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