Shared mechanisms in stemness and carcinogenesis: lessons from oncogenic viruses

A rise in technologies for epigenetic reprogramming of cells to pluripotency, highlights the potential of understanding and manipulating cellular plasticity in unprecedented ways. Increasing evidence points to shared mechanisms between cellular reprogramming and the carcinogenic process, with the em...

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Autores principales: Iacovides, Demetris, Michael, Stella, Achilleos, Charis, Strati, Katerina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872316/
https://www.ncbi.nlm.nih.gov/pubmed/24400225
http://dx.doi.org/10.3389/fcimb.2013.00066
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author Iacovides, Demetris
Michael, Stella
Achilleos, Charis
Strati, Katerina
author_facet Iacovides, Demetris
Michael, Stella
Achilleos, Charis
Strati, Katerina
author_sort Iacovides, Demetris
collection PubMed
description A rise in technologies for epigenetic reprogramming of cells to pluripotency, highlights the potential of understanding and manipulating cellular plasticity in unprecedented ways. Increasing evidence points to shared mechanisms between cellular reprogramming and the carcinogenic process, with the emerging possibility to harness these parallels in future therapeutics. In this review, we present a synopsis of recent work from oncogenic viruses which contributes to this body of knowledge, establishing a nexus between infection, cancer, and stemness.
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spelling pubmed-38723162014-01-07 Shared mechanisms in stemness and carcinogenesis: lessons from oncogenic viruses Iacovides, Demetris Michael, Stella Achilleos, Charis Strati, Katerina Front Cell Infect Microbiol Microbiology A rise in technologies for epigenetic reprogramming of cells to pluripotency, highlights the potential of understanding and manipulating cellular plasticity in unprecedented ways. Increasing evidence points to shared mechanisms between cellular reprogramming and the carcinogenic process, with the emerging possibility to harness these parallels in future therapeutics. In this review, we present a synopsis of recent work from oncogenic viruses which contributes to this body of knowledge, establishing a nexus between infection, cancer, and stemness. Frontiers Media S.A. 2013-12-25 /pmc/articles/PMC3872316/ /pubmed/24400225 http://dx.doi.org/10.3389/fcimb.2013.00066 Text en Copyright © 2013 Iacovides, Michael, Achilleos and Strati. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Iacovides, Demetris
Michael, Stella
Achilleos, Charis
Strati, Katerina
Shared mechanisms in stemness and carcinogenesis: lessons from oncogenic viruses
title Shared mechanisms in stemness and carcinogenesis: lessons from oncogenic viruses
title_full Shared mechanisms in stemness and carcinogenesis: lessons from oncogenic viruses
title_fullStr Shared mechanisms in stemness and carcinogenesis: lessons from oncogenic viruses
title_full_unstemmed Shared mechanisms in stemness and carcinogenesis: lessons from oncogenic viruses
title_short Shared mechanisms in stemness and carcinogenesis: lessons from oncogenic viruses
title_sort shared mechanisms in stemness and carcinogenesis: lessons from oncogenic viruses
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872316/
https://www.ncbi.nlm.nih.gov/pubmed/24400225
http://dx.doi.org/10.3389/fcimb.2013.00066
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