Cargando…

Mechanisms tagging senescent red blood cells for clearance in healthy humans

This review focuses on the analysis and evaluation of the diverse senescence markers suggested to prime red blood cells (RBC) for clearance in humans. These tags develop in the course of biochemical and structural alterations accompanying RBC aging, as the decrease of activities of multiple enzymes,...

Descripción completa

Detalles Bibliográficos
Autores principales: Lutz, Hans U., Bogdanova, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872327/
https://www.ncbi.nlm.nih.gov/pubmed/24399969
http://dx.doi.org/10.3389/fphys.2013.00387
_version_ 1782296947496845312
author Lutz, Hans U.
Bogdanova, Anna
author_facet Lutz, Hans U.
Bogdanova, Anna
author_sort Lutz, Hans U.
collection PubMed
description This review focuses on the analysis and evaluation of the diverse senescence markers suggested to prime red blood cells (RBC) for clearance in humans. These tags develop in the course of biochemical and structural alterations accompanying RBC aging, as the decrease of activities of multiple enzymes, the gradual accumulation of oxidative damage, the loss of membrane in form of microvesicles, the redistribution of ions and alterations in cell volume, density, and deformability. The actual tags represent the penultimate galactosyl residues, revealed by desialylation of glycophorins, or the aggregates of the anion exchanger (band 3 protein) to which anti-galactose antibodies bind in the first and anti-band 3 naturally occurring antibodies (NAbs) in the second case. While anti-band 3 NAbs bind to the carbohydrate-free portion of band 3 aggregates in healthy humans, induced anti-lactoferrin antibodies bind to the carbohydrate-containing portion of band 3 and along with anti-band 3 NAbs may accelerated clearance of senescent RBC in patients with anti-neutrophil cytoplasmic antibodies (ANCA). Exoplasmically accessible phosphatidylserine (PS) and the alterations in the interplay between CD47 on RBC and its receptor on macrophages, signal regulatory protein alpha (SIRPalpha protein), were also reported to induce erythrocyte clearance. We discuss the relevance of each mechanism and analyze the strength of the data.
format Online
Article
Text
id pubmed-3872327
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-38723272014-01-07 Mechanisms tagging senescent red blood cells for clearance in healthy humans Lutz, Hans U. Bogdanova, Anna Front Physiol Physiology This review focuses on the analysis and evaluation of the diverse senescence markers suggested to prime red blood cells (RBC) for clearance in humans. These tags develop in the course of biochemical and structural alterations accompanying RBC aging, as the decrease of activities of multiple enzymes, the gradual accumulation of oxidative damage, the loss of membrane in form of microvesicles, the redistribution of ions and alterations in cell volume, density, and deformability. The actual tags represent the penultimate galactosyl residues, revealed by desialylation of glycophorins, or the aggregates of the anion exchanger (band 3 protein) to which anti-galactose antibodies bind in the first and anti-band 3 naturally occurring antibodies (NAbs) in the second case. While anti-band 3 NAbs bind to the carbohydrate-free portion of band 3 aggregates in healthy humans, induced anti-lactoferrin antibodies bind to the carbohydrate-containing portion of band 3 and along with anti-band 3 NAbs may accelerated clearance of senescent RBC in patients with anti-neutrophil cytoplasmic antibodies (ANCA). Exoplasmically accessible phosphatidylserine (PS) and the alterations in the interplay between CD47 on RBC and its receptor on macrophages, signal regulatory protein alpha (SIRPalpha protein), were also reported to induce erythrocyte clearance. We discuss the relevance of each mechanism and analyze the strength of the data. Frontiers Media S.A. 2013-12-25 /pmc/articles/PMC3872327/ /pubmed/24399969 http://dx.doi.org/10.3389/fphys.2013.00387 Text en Copyright © 2013 Lutz and Bogdanova. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Lutz, Hans U.
Bogdanova, Anna
Mechanisms tagging senescent red blood cells for clearance in healthy humans
title Mechanisms tagging senescent red blood cells for clearance in healthy humans
title_full Mechanisms tagging senescent red blood cells for clearance in healthy humans
title_fullStr Mechanisms tagging senescent red blood cells for clearance in healthy humans
title_full_unstemmed Mechanisms tagging senescent red blood cells for clearance in healthy humans
title_short Mechanisms tagging senescent red blood cells for clearance in healthy humans
title_sort mechanisms tagging senescent red blood cells for clearance in healthy humans
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872327/
https://www.ncbi.nlm.nih.gov/pubmed/24399969
http://dx.doi.org/10.3389/fphys.2013.00387
work_keys_str_mv AT lutzhansu mechanismstaggingsenescentredbloodcellsforclearanceinhealthyhumans
AT bogdanovaanna mechanismstaggingsenescentredbloodcellsforclearanceinhealthyhumans