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Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study

Background. Prostate cancer (PCa) racial disparity is multifactorial, involving biological, sociocultural, and lifestyle determinants. We investigated the association between selected potentially functional polymorphisms (SNPs) and prostate cancer (PCa) risk in Black (AAM) and White (EAM) men. We fu...

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Autores principales: Chornokur, Ganna, Amankwah, Ernest K., Davis, Stacy N., Phelan, Catherine M., Park, Jong Y., Pow-Sang, Julio, Kumar, Nagi B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872424/
https://www.ncbi.nlm.nih.gov/pubmed/24386569
http://dx.doi.org/10.1155/2013/384594
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author Chornokur, Ganna
Amankwah, Ernest K.
Davis, Stacy N.
Phelan, Catherine M.
Park, Jong Y.
Pow-Sang, Julio
Kumar, Nagi B.
author_facet Chornokur, Ganna
Amankwah, Ernest K.
Davis, Stacy N.
Phelan, Catherine M.
Park, Jong Y.
Pow-Sang, Julio
Kumar, Nagi B.
author_sort Chornokur, Ganna
collection PubMed
description Background. Prostate cancer (PCa) racial disparity is multifactorial, involving biological, sociocultural, and lifestyle determinants. We investigated the association between selected potentially functional polymorphisms (SNPs) and prostate cancer (PCa) risk in Black (AAM) and White (EAM) men. We further explored if these associations varied by the body mass index (BMI) and height. Methods. Age-matched DNA samples from 259 AAM and 269 EAM were genotyped for 10 candidate SNPs in 7 genes using the TaqMan allelic differentiation analysis. The dominant, recessive, and additive age-adjusted unconditional logistic regression models were fitted. Results. Three SNPs showed statistically significant associations with PCa risk: in AAM, HNF1B rs7501939 (OR = 2.42, P = 0.0046) and rs4430796 (OR = 0.57, P = 0.0383); in EAM, CTBP2 rs4962416 (OR = 1.52, P = 0.0384). In addition, high BMI in AAM (OR = 1.06, P = 0.022) and height in EAM (OR = 0.92, P = 0.0434) showed significant associations. Interestingly, HNF1B rs7501939 was associated with PCa exclusively in obese AAM (OR = 2.14, P = 0.0103). Conclusion. Our results suggest that variation in the HNF1B may influence PCa risk in obese AAM.
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spelling pubmed-38724242014-01-02 Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study Chornokur, Ganna Amankwah, Ernest K. Davis, Stacy N. Phelan, Catherine M. Park, Jong Y. Pow-Sang, Julio Kumar, Nagi B. Prostate Cancer Research Article Background. Prostate cancer (PCa) racial disparity is multifactorial, involving biological, sociocultural, and lifestyle determinants. We investigated the association between selected potentially functional polymorphisms (SNPs) and prostate cancer (PCa) risk in Black (AAM) and White (EAM) men. We further explored if these associations varied by the body mass index (BMI) and height. Methods. Age-matched DNA samples from 259 AAM and 269 EAM were genotyped for 10 candidate SNPs in 7 genes using the TaqMan allelic differentiation analysis. The dominant, recessive, and additive age-adjusted unconditional logistic regression models were fitted. Results. Three SNPs showed statistically significant associations with PCa risk: in AAM, HNF1B rs7501939 (OR = 2.42, P = 0.0046) and rs4430796 (OR = 0.57, P = 0.0383); in EAM, CTBP2 rs4962416 (OR = 1.52, P = 0.0384). In addition, high BMI in AAM (OR = 1.06, P = 0.022) and height in EAM (OR = 0.92, P = 0.0434) showed significant associations. Interestingly, HNF1B rs7501939 was associated with PCa exclusively in obese AAM (OR = 2.14, P = 0.0103). Conclusion. Our results suggest that variation in the HNF1B may influence PCa risk in obese AAM. Hindawi Publishing Corporation 2013 2013-12-09 /pmc/articles/PMC3872424/ /pubmed/24386569 http://dx.doi.org/10.1155/2013/384594 Text en Copyright © 2013 Ganna Chornokur et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chornokur, Ganna
Amankwah, Ernest K.
Davis, Stacy N.
Phelan, Catherine M.
Park, Jong Y.
Pow-Sang, Julio
Kumar, Nagi B.
Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study
title Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study
title_full Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study
title_fullStr Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study
title_full_unstemmed Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study
title_short Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study
title_sort variation in hnf1b and obesity may influence prostate cancer risk in african american men: a pilot study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872424/
https://www.ncbi.nlm.nih.gov/pubmed/24386569
http://dx.doi.org/10.1155/2013/384594
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