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ART outcome in young women with premature ovarian aging
BACKGROUND: Young women with signs of ovarian aging are a matter of concern as far as their reproductive performance is concerned. With more women approaching infertility centers with this problem, it becomes necessary to understand what reproductive outcomes are possible in such cases. Female age a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872670/ https://www.ncbi.nlm.nih.gov/pubmed/24381465 http://dx.doi.org/10.4103/0976-7800.122257 |
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author | Dua, Meenakshi Bhatia, Vandana Malik, Sonia Prakash, Ved |
author_facet | Dua, Meenakshi Bhatia, Vandana Malik, Sonia Prakash, Ved |
author_sort | Dua, Meenakshi |
collection | PubMed |
description | BACKGROUND: Young women with signs of ovarian aging are a matter of concern as far as their reproductive performance is concerned. With more women approaching infertility centers with this problem, it becomes necessary to understand what reproductive outcomes are possible in such cases. Female age and basal Follicle stimulating hormone (FSH) level, both are strong independent predictors of In Vitro Fertilization (IVF) outcome. OBJECTIVE: To correlate age-related basal FSH with IVF outcome in women with premature ovarian aging in gonadotropins-induced cycles. MATERIALS AND METHODS: Between January 2011 and October 2012, a total of 135 women undergoing IVF and ICSI cycles with antagonist protocol were included in this retrospective cohort study. Basal FSH concentrations were measured and the women's ages were calculated before they were undergoing pituitary desensitization and its correlation with assisted reproduction technique (ART) outcome was evaluated. RESULTS: Increasing FSH was associated significantly with reduced number of oocytes retrieved, and embryos obtained. Young women with high FSH up to 20 produced less but good quality embryo's resulting in sound pregnancy rate. CONCLUSION: FSH is a quantitative and age is a qualitative measure of ovarian reserve. Both are equally important in predicting IVF outcome. Basal FSH concentration should be restricted to counseling of patients on probability of achieving pregnancy, but should not be used to exclude them from fertility treatment. |
format | Online Article Text |
id | pubmed-3872670 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38726702013-12-31 ART outcome in young women with premature ovarian aging Dua, Meenakshi Bhatia, Vandana Malik, Sonia Prakash, Ved J Midlife Health Original Article BACKGROUND: Young women with signs of ovarian aging are a matter of concern as far as their reproductive performance is concerned. With more women approaching infertility centers with this problem, it becomes necessary to understand what reproductive outcomes are possible in such cases. Female age and basal Follicle stimulating hormone (FSH) level, both are strong independent predictors of In Vitro Fertilization (IVF) outcome. OBJECTIVE: To correlate age-related basal FSH with IVF outcome in women with premature ovarian aging in gonadotropins-induced cycles. MATERIALS AND METHODS: Between January 2011 and October 2012, a total of 135 women undergoing IVF and ICSI cycles with antagonist protocol were included in this retrospective cohort study. Basal FSH concentrations were measured and the women's ages were calculated before they were undergoing pituitary desensitization and its correlation with assisted reproduction technique (ART) outcome was evaluated. RESULTS: Increasing FSH was associated significantly with reduced number of oocytes retrieved, and embryos obtained. Young women with high FSH up to 20 produced less but good quality embryo's resulting in sound pregnancy rate. CONCLUSION: FSH is a quantitative and age is a qualitative measure of ovarian reserve. Both are equally important in predicting IVF outcome. Basal FSH concentration should be restricted to counseling of patients on probability of achieving pregnancy, but should not be used to exclude them from fertility treatment. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3872670/ /pubmed/24381465 http://dx.doi.org/10.4103/0976-7800.122257 Text en Copyright: © Journal of Mid-life Health http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Dua, Meenakshi Bhatia, Vandana Malik, Sonia Prakash, Ved ART outcome in young women with premature ovarian aging |
title | ART outcome in young women with premature ovarian aging |
title_full | ART outcome in young women with premature ovarian aging |
title_fullStr | ART outcome in young women with premature ovarian aging |
title_full_unstemmed | ART outcome in young women with premature ovarian aging |
title_short | ART outcome in young women with premature ovarian aging |
title_sort | art outcome in young women with premature ovarian aging |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872670/ https://www.ncbi.nlm.nih.gov/pubmed/24381465 http://dx.doi.org/10.4103/0976-7800.122257 |
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