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ART outcome in young women with premature ovarian aging

BACKGROUND: Young women with signs of ovarian aging are a matter of concern as far as their reproductive performance is concerned. With more women approaching infertility centers with this problem, it becomes necessary to understand what reproductive outcomes are possible in such cases. Female age a...

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Autores principales: Dua, Meenakshi, Bhatia, Vandana, Malik, Sonia, Prakash, Ved
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872670/
https://www.ncbi.nlm.nih.gov/pubmed/24381465
http://dx.doi.org/10.4103/0976-7800.122257
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author Dua, Meenakshi
Bhatia, Vandana
Malik, Sonia
Prakash, Ved
author_facet Dua, Meenakshi
Bhatia, Vandana
Malik, Sonia
Prakash, Ved
author_sort Dua, Meenakshi
collection PubMed
description BACKGROUND: Young women with signs of ovarian aging are a matter of concern as far as their reproductive performance is concerned. With more women approaching infertility centers with this problem, it becomes necessary to understand what reproductive outcomes are possible in such cases. Female age and basal Follicle stimulating hormone (FSH) level, both are strong independent predictors of In Vitro Fertilization (IVF) outcome. OBJECTIVE: To correlate age-related basal FSH with IVF outcome in women with premature ovarian aging in gonadotropins-induced cycles. MATERIALS AND METHODS: Between January 2011 and October 2012, a total of 135 women undergoing IVF and ICSI cycles with antagonist protocol were included in this retrospective cohort study. Basal FSH concentrations were measured and the women's ages were calculated before they were undergoing pituitary desensitization and its correlation with assisted reproduction technique (ART) outcome was evaluated. RESULTS: Increasing FSH was associated significantly with reduced number of oocytes retrieved, and embryos obtained. Young women with high FSH up to 20 produced less but good quality embryo's resulting in sound pregnancy rate. CONCLUSION: FSH is a quantitative and age is a qualitative measure of ovarian reserve. Both are equally important in predicting IVF outcome. Basal FSH concentration should be restricted to counseling of patients on probability of achieving pregnancy, but should not be used to exclude them from fertility treatment.
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spelling pubmed-38726702013-12-31 ART outcome in young women with premature ovarian aging Dua, Meenakshi Bhatia, Vandana Malik, Sonia Prakash, Ved J Midlife Health Original Article BACKGROUND: Young women with signs of ovarian aging are a matter of concern as far as their reproductive performance is concerned. With more women approaching infertility centers with this problem, it becomes necessary to understand what reproductive outcomes are possible in such cases. Female age and basal Follicle stimulating hormone (FSH) level, both are strong independent predictors of In Vitro Fertilization (IVF) outcome. OBJECTIVE: To correlate age-related basal FSH with IVF outcome in women with premature ovarian aging in gonadotropins-induced cycles. MATERIALS AND METHODS: Between January 2011 and October 2012, a total of 135 women undergoing IVF and ICSI cycles with antagonist protocol were included in this retrospective cohort study. Basal FSH concentrations were measured and the women's ages were calculated before they were undergoing pituitary desensitization and its correlation with assisted reproduction technique (ART) outcome was evaluated. RESULTS: Increasing FSH was associated significantly with reduced number of oocytes retrieved, and embryos obtained. Young women with high FSH up to 20 produced less but good quality embryo's resulting in sound pregnancy rate. CONCLUSION: FSH is a quantitative and age is a qualitative measure of ovarian reserve. Both are equally important in predicting IVF outcome. Basal FSH concentration should be restricted to counseling of patients on probability of achieving pregnancy, but should not be used to exclude them from fertility treatment. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3872670/ /pubmed/24381465 http://dx.doi.org/10.4103/0976-7800.122257 Text en Copyright: © Journal of Mid-life Health http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Dua, Meenakshi
Bhatia, Vandana
Malik, Sonia
Prakash, Ved
ART outcome in young women with premature ovarian aging
title ART outcome in young women with premature ovarian aging
title_full ART outcome in young women with premature ovarian aging
title_fullStr ART outcome in young women with premature ovarian aging
title_full_unstemmed ART outcome in young women with premature ovarian aging
title_short ART outcome in young women with premature ovarian aging
title_sort art outcome in young women with premature ovarian aging
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872670/
https://www.ncbi.nlm.nih.gov/pubmed/24381465
http://dx.doi.org/10.4103/0976-7800.122257
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