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Does blood transfusion affect pituitary gonadal axis and sperm parameters in young males with sickle cell disease?

OBJECTIVE: We evaluated the effect of packed red cell transfusion (PCTx) on serum concentrations of gonadotropins luteinizing hormone and follicle-stimulating hormone (LH and FSH) and testosterone (T) levels and measured sperm parameters in young adults with sickle cell disease (SCD) on top-up trans...

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Autores principales: Soliman, Ashraf T., Yasin, Mohamed, El-Awwa, Ahmed, Abdelrahman, Mohamed O., De Sanctis, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872712/
https://www.ncbi.nlm.nih.gov/pubmed/24381868
http://dx.doi.org/10.4103/2230-8210.122599
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author Soliman, Ashraf T.
Yasin, Mohamed
El-Awwa, Ahmed
Abdelrahman, Mohamed O.
De Sanctis, Vincenzo
author_facet Soliman, Ashraf T.
Yasin, Mohamed
El-Awwa, Ahmed
Abdelrahman, Mohamed O.
De Sanctis, Vincenzo
author_sort Soliman, Ashraf T.
collection PubMed
description OBJECTIVE: We evaluated the effect of packed red cell transfusion (PCTx) on serum concentrations of gonadotropins luteinizing hormone and follicle-stimulating hormone (LH and FSH) and testosterone (T) levels and measured sperm parameters in young adults with sickle cell disease (SCD) on top-up transfusion (TTx) and those on exchange transfusion (ETx) regimen. MATERIALS AND METHODS: Basal serum concentrations of FSH, LH, and T and semen parameters were evaluated before and 7 days after PCTx in 18 young adults with transfusion-dependent SCD, aged 20.7 ± 2.88 years. They had full pubertal development (Tanner's stage 5), and capacity to ejaculate. They were regularly transfused since early childhood. Chelation therapy was started early during the first 2 years of life using desferrioxamine and was replaced by deferasirox for the last 4-5 years. Ten patients were on TTx and eight were on ETx regimen. RESULTS: PCTx significantly increased hemoglobin (Hb) from 8.5 ± 1.17 g/dl to 10.5 ± 0.4 g/dl, T from 12.3 ± 1.24 nmol/L to 14.23 ± 1.22 nmol/L and gonadotropins’ concentrations. Sperm parameters improved significantly after PCTx including: total sperm count from 87.4 ± 24.6 million/ml to 146.2 ± 51.25 million/ml, total progressive sperm motility (TPM) from 40.8 ± 11.1 million/ml to 93.4 ± 38.3 million/ml, rapid progressive sperm motility (RPM) progressive motility from 29.26 ± 8.75 million/ml to 67.4 ± 29 million/ml. After PCTx the total sperm count, TPM and RPM were significantly better in the ETx group versus the TTx group. Before and after PCTx, T concentrations were correlated significantly with sperm total count, volume, TPM and RPM (r = 0.53, 0.55, 0.42, and 0.38, respectively, P < 0.01). Hb concentrations were correlated significantly with sperm count, TPM, RPM, and % of sperms with normal morphology (r = 0.60, 0.69, 0.66, and 0.86, respectively, P < 0.001). CONCLUSION: Our study suggests that in males with SCD blood transfusion is associated with significant acute enhancement of sperm parameters and with increased concentrations of serum T, LH, and FSH. Improvement of sperm parameters were significantly better in the ETx group verses the TTx group. These “acute” effects on spermiogenesis are reached with an unknown mechanism/s and suggest a number of pathways that need further human and/or experimental studies.
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spelling pubmed-38727122013-12-31 Does blood transfusion affect pituitary gonadal axis and sperm parameters in young males with sickle cell disease? Soliman, Ashraf T. Yasin, Mohamed El-Awwa, Ahmed Abdelrahman, Mohamed O. De Sanctis, Vincenzo Indian J Endocrinol Metab Endocrinology and Gender OBJECTIVE: We evaluated the effect of packed red cell transfusion (PCTx) on serum concentrations of gonadotropins luteinizing hormone and follicle-stimulating hormone (LH and FSH) and testosterone (T) levels and measured sperm parameters in young adults with sickle cell disease (SCD) on top-up transfusion (TTx) and those on exchange transfusion (ETx) regimen. MATERIALS AND METHODS: Basal serum concentrations of FSH, LH, and T and semen parameters were evaluated before and 7 days after PCTx in 18 young adults with transfusion-dependent SCD, aged 20.7 ± 2.88 years. They had full pubertal development (Tanner's stage 5), and capacity to ejaculate. They were regularly transfused since early childhood. Chelation therapy was started early during the first 2 years of life using desferrioxamine and was replaced by deferasirox for the last 4-5 years. Ten patients were on TTx and eight were on ETx regimen. RESULTS: PCTx significantly increased hemoglobin (Hb) from 8.5 ± 1.17 g/dl to 10.5 ± 0.4 g/dl, T from 12.3 ± 1.24 nmol/L to 14.23 ± 1.22 nmol/L and gonadotropins’ concentrations. Sperm parameters improved significantly after PCTx including: total sperm count from 87.4 ± 24.6 million/ml to 146.2 ± 51.25 million/ml, total progressive sperm motility (TPM) from 40.8 ± 11.1 million/ml to 93.4 ± 38.3 million/ml, rapid progressive sperm motility (RPM) progressive motility from 29.26 ± 8.75 million/ml to 67.4 ± 29 million/ml. After PCTx the total sperm count, TPM and RPM were significantly better in the ETx group versus the TTx group. Before and after PCTx, T concentrations were correlated significantly with sperm total count, volume, TPM and RPM (r = 0.53, 0.55, 0.42, and 0.38, respectively, P < 0.01). Hb concentrations were correlated significantly with sperm count, TPM, RPM, and % of sperms with normal morphology (r = 0.60, 0.69, 0.66, and 0.86, respectively, P < 0.001). CONCLUSION: Our study suggests that in males with SCD blood transfusion is associated with significant acute enhancement of sperm parameters and with increased concentrations of serum T, LH, and FSH. Improvement of sperm parameters were significantly better in the ETx group verses the TTx group. These “acute” effects on spermiogenesis are reached with an unknown mechanism/s and suggest a number of pathways that need further human and/or experimental studies. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3872712/ /pubmed/24381868 http://dx.doi.org/10.4103/2230-8210.122599 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Endocrinology and Gender
Soliman, Ashraf T.
Yasin, Mohamed
El-Awwa, Ahmed
Abdelrahman, Mohamed O.
De Sanctis, Vincenzo
Does blood transfusion affect pituitary gonadal axis and sperm parameters in young males with sickle cell disease?
title Does blood transfusion affect pituitary gonadal axis and sperm parameters in young males with sickle cell disease?
title_full Does blood transfusion affect pituitary gonadal axis and sperm parameters in young males with sickle cell disease?
title_fullStr Does blood transfusion affect pituitary gonadal axis and sperm parameters in young males with sickle cell disease?
title_full_unstemmed Does blood transfusion affect pituitary gonadal axis and sperm parameters in young males with sickle cell disease?
title_short Does blood transfusion affect pituitary gonadal axis and sperm parameters in young males with sickle cell disease?
title_sort does blood transfusion affect pituitary gonadal axis and sperm parameters in young males with sickle cell disease?
topic Endocrinology and Gender
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872712/
https://www.ncbi.nlm.nih.gov/pubmed/24381868
http://dx.doi.org/10.4103/2230-8210.122599
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