Cargando…

Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases

White matter dysfunction is an important part of many CNS disorders including multiple sclerosis (MS) and vascular dementia. Within injured areas, myelin loss and oligodendrocyte death may trigger endogenous attempts at regeneration. However, during disease progression, remyelination failure may eve...

Descripción completa

Detalles Bibliográficos
Autores principales: Maki, Takakuni, Liang, Anna C., Miyamoto, Nobukazu, Lo, Eng H., Arai, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872787/
https://www.ncbi.nlm.nih.gov/pubmed/24421755
http://dx.doi.org/10.3389/fncel.2013.00275
_version_ 1782297021441376256
author Maki, Takakuni
Liang, Anna C.
Miyamoto, Nobukazu
Lo, Eng H.
Arai, Ken
author_facet Maki, Takakuni
Liang, Anna C.
Miyamoto, Nobukazu
Lo, Eng H.
Arai, Ken
author_sort Maki, Takakuni
collection PubMed
description White matter dysfunction is an important part of many CNS disorders including multiple sclerosis (MS) and vascular dementia. Within injured areas, myelin loss and oligodendrocyte death may trigger endogenous attempts at regeneration. However, during disease progression, remyelination failure may eventually occur due to impaired survival/proliferation, migration/recruitment, and differentiation of oligodendrocyte precursor cells (OPCs). The ventricular-subventricular zone (V-SVZ) and the subgranular zone (SGZ) are the main sources of neural stem/progenitor cells (NSPCs), which can give rise to neurons as well as OPCs. Under normal conditions in the adult brain, the V-SVZ progenitors generate a large number of neurons with a small number of oligodendrocyte lineage cells. However, after demyelination, the fate of V-SVZ-derived progenitor cells shifts from neurons to OPCs, and these newly generated OPCs migrate to the demyelinating lesions to ease white matter damage. In this mini-review, we will summarize the recent studies on extrinsic (e.g., vasculature, extracellular matrix (ECM), cerebrospinal fluid (CSF)) and intrinsic (e.g., transcription factors, epigenetic modifiers) factors, which mediate oligodendrocyte generation from the V-SVZ progenitor cells. A deeper understanding of the mechanisms that regulate the fate of V-SVZ progenitor cells may lead to new therapeutic approaches for ameliorating white matter dysfunction and damage in CNS disorders.
format Online
Article
Text
id pubmed-3872787
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-38727872014-01-13 Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases Maki, Takakuni Liang, Anna C. Miyamoto, Nobukazu Lo, Eng H. Arai, Ken Front Cell Neurosci Neuroscience White matter dysfunction is an important part of many CNS disorders including multiple sclerosis (MS) and vascular dementia. Within injured areas, myelin loss and oligodendrocyte death may trigger endogenous attempts at regeneration. However, during disease progression, remyelination failure may eventually occur due to impaired survival/proliferation, migration/recruitment, and differentiation of oligodendrocyte precursor cells (OPCs). The ventricular-subventricular zone (V-SVZ) and the subgranular zone (SGZ) are the main sources of neural stem/progenitor cells (NSPCs), which can give rise to neurons as well as OPCs. Under normal conditions in the adult brain, the V-SVZ progenitors generate a large number of neurons with a small number of oligodendrocyte lineage cells. However, after demyelination, the fate of V-SVZ-derived progenitor cells shifts from neurons to OPCs, and these newly generated OPCs migrate to the demyelinating lesions to ease white matter damage. In this mini-review, we will summarize the recent studies on extrinsic (e.g., vasculature, extracellular matrix (ECM), cerebrospinal fluid (CSF)) and intrinsic (e.g., transcription factors, epigenetic modifiers) factors, which mediate oligodendrocyte generation from the V-SVZ progenitor cells. A deeper understanding of the mechanisms that regulate the fate of V-SVZ progenitor cells may lead to new therapeutic approaches for ameliorating white matter dysfunction and damage in CNS disorders. Frontiers Media S.A. 2013-12-26 /pmc/articles/PMC3872787/ /pubmed/24421755 http://dx.doi.org/10.3389/fncel.2013.00275 Text en Copyright © 2013 Maki, Liang, Miyamoto, Lo and Arai. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Maki, Takakuni
Liang, Anna C.
Miyamoto, Nobukazu
Lo, Eng H.
Arai, Ken
Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases
title Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases
title_full Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases
title_fullStr Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases
title_full_unstemmed Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases
title_short Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases
title_sort mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872787/
https://www.ncbi.nlm.nih.gov/pubmed/24421755
http://dx.doi.org/10.3389/fncel.2013.00275
work_keys_str_mv AT makitakakuni mechanismsofoligodendrocyteregenerationfromventricularsubventricularzonederivedprogenitorcellsinwhitematterdiseases
AT liangannac mechanismsofoligodendrocyteregenerationfromventricularsubventricularzonederivedprogenitorcellsinwhitematterdiseases
AT miyamotonobukazu mechanismsofoligodendrocyteregenerationfromventricularsubventricularzonederivedprogenitorcellsinwhitematterdiseases
AT loengh mechanismsofoligodendrocyteregenerationfromventricularsubventricularzonederivedprogenitorcellsinwhitematterdiseases
AT araiken mechanismsofoligodendrocyteregenerationfromventricularsubventricularzonederivedprogenitorcellsinwhitematterdiseases