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Yeast Prions: Protein Aggregation Is Not Enough

Although many proteins -- both damaged and normal -- have a tendency to aggregate, only some are capable of dividing and propagating. What does it take to turn a protein aggregate into an infectious prion?

Detalles Bibliográficos
Autor principal: Sherman, Michael Y
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387287/
https://www.ncbi.nlm.nih.gov/pubmed/15094820
http://dx.doi.org/10.1371/journal.pbio.0020125
Descripción
Sumario:Although many proteins -- both damaged and normal -- have a tendency to aggregate, only some are capable of dividing and propagating. What does it take to turn a protein aggregate into an infectious prion?