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Clinical experience with biphasic insulin aspart in people with type 2 diabetes: Results from the Libya cohort of the A(1)chieve study

BACKGROUND: The A(1)chieve, a multicentric (28 countries), 24-week, non-interventional study evaluated the safety and effectiveness of insulin detemir, biphasic insulin aspart and insulin aspart in people with T2DM (n = 66,726) in routine clinical care across four continents. MATERIALS AND METHODS:...

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Autores principales: Hajjaji, Issam M., Sherif, Ibrahim, Elazrag, Aisha, Jaber, Suhair, Chakkarwar, Praful N, Eltabal, Salem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872883/
https://www.ncbi.nlm.nih.gov/pubmed/24404475
http://dx.doi.org/10.4103/2230-8210.122062
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author Hajjaji, Issam M.
Sherif, Ibrahim
Elazrag, Aisha
Jaber, Suhair
Chakkarwar, Praful N
Eltabal, Salem
author_facet Hajjaji, Issam M.
Sherif, Ibrahim
Elazrag, Aisha
Jaber, Suhair
Chakkarwar, Praful N
Eltabal, Salem
author_sort Hajjaji, Issam M.
collection PubMed
description BACKGROUND: The A(1)chieve, a multicentric (28 countries), 24-week, non-interventional study evaluated the safety and effectiveness of insulin detemir, biphasic insulin aspart and insulin aspart in people with T2DM (n = 66,726) in routine clinical care across four continents. MATERIALS AND METHODS: Data was collected at baseline, at 12 weeks and at 24 weeks. This short communication presents the results for patients enrolled in biphasic insulin aspart sub group from Libya. RESULTS: A total of 179 patients were enrolled in the biphasic insulin aspart subgroup. All the patients were prior insulin users. At baseline glycaemic control was poor (mean HbA(1)c: 9.3%). After 24 weeks of treatment there was an improvement in HbA(1)c (−0.9%). Hypoglycaemic events reduced from 7.2 events/patient-year to 3.7 events/patient-year in 24 weeks. SADRs did not occur in any of the study patients. CONCLUSION: Starting or switching to biphasic insulin aspart was associated with improvement in glycaemic control with a low rate of hypoglycaemia.
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spelling pubmed-38728832014-01-08 Clinical experience with biphasic insulin aspart in people with type 2 diabetes: Results from the Libya cohort of the A(1)chieve study Hajjaji, Issam M. Sherif, Ibrahim Elazrag, Aisha Jaber, Suhair Chakkarwar, Praful N Eltabal, Salem Indian J Endocrinol Metab Original Article BACKGROUND: The A(1)chieve, a multicentric (28 countries), 24-week, non-interventional study evaluated the safety and effectiveness of insulin detemir, biphasic insulin aspart and insulin aspart in people with T2DM (n = 66,726) in routine clinical care across four continents. MATERIALS AND METHODS: Data was collected at baseline, at 12 weeks and at 24 weeks. This short communication presents the results for patients enrolled in biphasic insulin aspart sub group from Libya. RESULTS: A total of 179 patients were enrolled in the biphasic insulin aspart subgroup. All the patients were prior insulin users. At baseline glycaemic control was poor (mean HbA(1)c: 9.3%). After 24 weeks of treatment there was an improvement in HbA(1)c (−0.9%). Hypoglycaemic events reduced from 7.2 events/patient-year to 3.7 events/patient-year in 24 weeks. SADRs did not occur in any of the study patients. CONCLUSION: Starting or switching to biphasic insulin aspart was associated with improvement in glycaemic control with a low rate of hypoglycaemia. Medknow Publications & Media Pvt Ltd 2013-11 /pmc/articles/PMC3872883/ /pubmed/24404475 http://dx.doi.org/10.4103/2230-8210.122062 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hajjaji, Issam M.
Sherif, Ibrahim
Elazrag, Aisha
Jaber, Suhair
Chakkarwar, Praful N
Eltabal, Salem
Clinical experience with biphasic insulin aspart in people with type 2 diabetes: Results from the Libya cohort of the A(1)chieve study
title Clinical experience with biphasic insulin aspart in people with type 2 diabetes: Results from the Libya cohort of the A(1)chieve study
title_full Clinical experience with biphasic insulin aspart in people with type 2 diabetes: Results from the Libya cohort of the A(1)chieve study
title_fullStr Clinical experience with biphasic insulin aspart in people with type 2 diabetes: Results from the Libya cohort of the A(1)chieve study
title_full_unstemmed Clinical experience with biphasic insulin aspart in people with type 2 diabetes: Results from the Libya cohort of the A(1)chieve study
title_short Clinical experience with biphasic insulin aspart in people with type 2 diabetes: Results from the Libya cohort of the A(1)chieve study
title_sort clinical experience with biphasic insulin aspart in people with type 2 diabetes: results from the libya cohort of the a(1)chieve study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872883/
https://www.ncbi.nlm.nih.gov/pubmed/24404475
http://dx.doi.org/10.4103/2230-8210.122062
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