Cargando…
Clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the Qatar cohort of the A(1)chieve study
BACKGROUND: The A(1)chieve, a multicentric (28 countries), 24-week, non-interventional study evaluated the safety and effectiveness of insulin detemir, biphasic insulin aspart and insulin aspart in people with T2DM (n = 66,726) in routine clinical care across four continents. MATERIALS AND METHODS:...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872892/ https://www.ncbi.nlm.nih.gov/pubmed/24404484 http://dx.doi.org/10.4103/2230-8210.122081 |
_version_ | 1782297033178087424 |
---|---|
author | Daghash, Mohamed Hasan Raja, Jabbar Mubarak Milad, Mohamed |
author_facet | Daghash, Mohamed Hasan Raja, Jabbar Mubarak Milad, Mohamed |
author_sort | Daghash, Mohamed Hasan |
collection | PubMed |
description | BACKGROUND: The A(1)chieve, a multicentric (28 countries), 24-week, non-interventional study evaluated the safety and effectiveness of insulin detemir, biphasic insulin aspart and insulin aspart in people with T2DM (n = 66,726) in routine clinical care across four continents. MATERIALS AND METHODS: Data was collected at baseline, at 12 weeks and at 24 weeks. This short communication presents the results for patients enrolled from Qatar. RESULTS: A total of 91 patients were enrolled in the study. Two insulin analogue regimens were used in the study. Study patients had started on or were switched to biphasic insulin aspart (n = 88), insulin detemir (n = 2), and other insulin combinations (n = 1). At baseline glycaemic control was poor for both insulin naïve (mean HbA(1)c: 10.9%) and insulin users (mean HbA(1)c: 9.1%) groups. After 24 weeks of treatment, all the study groups showed improvement in HbA(1)c (insulin naïve: −1.8%, insulin users: −1.3%). Major hypoglycaemia did not occur in the study patients. SADRs were reported in 1.4% of insulin users. CONCLUSION: Starting or switching to insulin analogues was associated with improvement in glycaemic control with a low rate of hypoglycaemia. |
format | Online Article Text |
id | pubmed-3872892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38728922014-01-08 Clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the Qatar cohort of the A(1)chieve study Daghash, Mohamed Hasan Raja, Jabbar Mubarak Milad, Mohamed Indian J Endocrinol Metab Original Article BACKGROUND: The A(1)chieve, a multicentric (28 countries), 24-week, non-interventional study evaluated the safety and effectiveness of insulin detemir, biphasic insulin aspart and insulin aspart in people with T2DM (n = 66,726) in routine clinical care across four continents. MATERIALS AND METHODS: Data was collected at baseline, at 12 weeks and at 24 weeks. This short communication presents the results for patients enrolled from Qatar. RESULTS: A total of 91 patients were enrolled in the study. Two insulin analogue regimens were used in the study. Study patients had started on or were switched to biphasic insulin aspart (n = 88), insulin detemir (n = 2), and other insulin combinations (n = 1). At baseline glycaemic control was poor for both insulin naïve (mean HbA(1)c: 10.9%) and insulin users (mean HbA(1)c: 9.1%) groups. After 24 weeks of treatment, all the study groups showed improvement in HbA(1)c (insulin naïve: −1.8%, insulin users: −1.3%). Major hypoglycaemia did not occur in the study patients. SADRs were reported in 1.4% of insulin users. CONCLUSION: Starting or switching to insulin analogues was associated with improvement in glycaemic control with a low rate of hypoglycaemia. Medknow Publications & Media Pvt Ltd 2013-11 /pmc/articles/PMC3872892/ /pubmed/24404484 http://dx.doi.org/10.4103/2230-8210.122081 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Daghash, Mohamed Hasan Raja, Jabbar Mubarak Milad, Mohamed Clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the Qatar cohort of the A(1)chieve study |
title | Clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the Qatar cohort of the A(1)chieve study |
title_full | Clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the Qatar cohort of the A(1)chieve study |
title_fullStr | Clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the Qatar cohort of the A(1)chieve study |
title_full_unstemmed | Clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the Qatar cohort of the A(1)chieve study |
title_short | Clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the Qatar cohort of the A(1)chieve study |
title_sort | clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: results from the qatar cohort of the a(1)chieve study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872892/ https://www.ncbi.nlm.nih.gov/pubmed/24404484 http://dx.doi.org/10.4103/2230-8210.122081 |
work_keys_str_mv | AT daghashmohamedhasan clinicalexperiencewithinsulindetemirbiphasicinsulinaspartandinsulinaspartinpeoplewithtype2diabetesresultsfromtheqatarcohortofthea1chievestudy AT rajajabbarmubarak clinicalexperiencewithinsulindetemirbiphasicinsulinaspartandinsulinaspartinpeoplewithtype2diabetesresultsfromtheqatarcohortofthea1chievestudy AT miladmohamed clinicalexperiencewithinsulindetemirbiphasicinsulinaspartandinsulinaspartinpeoplewithtype2diabetesresultsfromtheqatarcohortofthea1chievestudy |