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The Role of Mass Spectrometry in the “Omics” Era
Mass spectrometry (MS) is one of the key analytical technology on which the emerging ‘‘-omics’’ approaches are based. It may provide detection and quantization of thousands of proteins and biologically active metabolites from a tissue, body fluid or cell culture working in a ‘‘global’’ or ‘‘targeted...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bentham Science Publishers
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873040/ https://www.ncbi.nlm.nih.gov/pubmed/24376367 http://dx.doi.org/10.2174/1385272817888131118162725 |
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author | Di Girolamo, Francesco Lante, Isabella Muraca, Maurizio Putignani, Lorenza |
author_facet | Di Girolamo, Francesco Lante, Isabella Muraca, Maurizio Putignani, Lorenza |
author_sort | Di Girolamo, Francesco |
collection | PubMed |
description | Mass spectrometry (MS) is one of the key analytical technology on which the emerging ‘‘-omics’’ approaches are based. It may provide detection and quantization of thousands of proteins and biologically active metabolites from a tissue, body fluid or cell culture working in a ‘‘global’’ or ‘‘targeted’’ manner, down to ultra-trace levels. It can be expected that the high performance of MS technology, coupled to routine data handling, will soon bring fruit in the request for a better understanding of human diseases, leading to new molecular biomarkers, hence affecting drug targets and therapies. In this review, we focus on the main advances in the MS technologies, influencing genomics, transcriptomics, proteomics, lipidomics and metabolomics fields, up to the most recent MS applications to meta-omic studies. |
format | Online Article Text |
id | pubmed-3873040 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-38730402013-12-27 The Role of Mass Spectrometry in the “Omics” Era Di Girolamo, Francesco Lante, Isabella Muraca, Maurizio Putignani, Lorenza Curr Org Chem Article Mass spectrometry (MS) is one of the key analytical technology on which the emerging ‘‘-omics’’ approaches are based. It may provide detection and quantization of thousands of proteins and biologically active metabolites from a tissue, body fluid or cell culture working in a ‘‘global’’ or ‘‘targeted’’ manner, down to ultra-trace levels. It can be expected that the high performance of MS technology, coupled to routine data handling, will soon bring fruit in the request for a better understanding of human diseases, leading to new molecular biomarkers, hence affecting drug targets and therapies. In this review, we focus on the main advances in the MS technologies, influencing genomics, transcriptomics, proteomics, lipidomics and metabolomics fields, up to the most recent MS applications to meta-omic studies. Bentham Science Publishers 2013-12 2013-12 /pmc/articles/PMC3873040/ /pubmed/24376367 http://dx.doi.org/10.2174/1385272817888131118162725 Text en © 2013 Bentham Science Publishers http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Di Girolamo, Francesco Lante, Isabella Muraca, Maurizio Putignani, Lorenza The Role of Mass Spectrometry in the “Omics” Era |
title | The Role of Mass Spectrometry in the “Omics” Era |
title_full | The Role of Mass Spectrometry in the “Omics” Era |
title_fullStr | The Role of Mass Spectrometry in the “Omics” Era |
title_full_unstemmed | The Role of Mass Spectrometry in the “Omics” Era |
title_short | The Role of Mass Spectrometry in the “Omics” Era |
title_sort | role of mass spectrometry in the “omics” era |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873040/ https://www.ncbi.nlm.nih.gov/pubmed/24376367 http://dx.doi.org/10.2174/1385272817888131118162725 |
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