Immunohistochemical Studies of the Kynurenine Pathway in Morphea

Cutaneous sclerosis, resembling that seen in subcutaneous morphea, is a feature of eosinophilic fasciitis and eosinophilia-myalgia syndrome, two conditions in which the kynurenine pathway is known to be activated. To investigate the possibility of activation of the kynurenine pathway in morphea, ski...

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Detalles Bibliográficos
Autores principales: Noakes, Rowland, Mellick, Nick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873171/
https://www.ncbi.nlm.nih.gov/pubmed/24385714
http://dx.doi.org/10.4137/IJTR.S13371
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author Noakes, Rowland
Mellick, Nick
author_facet Noakes, Rowland
Mellick, Nick
author_sort Noakes, Rowland
collection PubMed
description Cutaneous sclerosis, resembling that seen in subcutaneous morphea, is a feature of eosinophilic fasciitis and eosinophilia-myalgia syndrome, two conditions in which the kynurenine pathway is known to be activated. To investigate the possibility of activation of the kynurenine pathway in morphea, skin biopsies were taken from involved and non-involved sites in a series of three patients with morphea. Immunohistochemical stains for quinolinic acid and indoleamine 2,3-dioxygenase (IDO) were performed.
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spelling pubmed-38731712014-01-02 Immunohistochemical Studies of the Kynurenine Pathway in Morphea Noakes, Rowland Mellick, Nick Int J Tryptophan Res Original Research Cutaneous sclerosis, resembling that seen in subcutaneous morphea, is a feature of eosinophilic fasciitis and eosinophilia-myalgia syndrome, two conditions in which the kynurenine pathway is known to be activated. To investigate the possibility of activation of the kynurenine pathway in morphea, skin biopsies were taken from involved and non-involved sites in a series of three patients with morphea. Immunohistochemical stains for quinolinic acid and indoleamine 2,3-dioxygenase (IDO) were performed. Libertas Academica 2013-12-23 /pmc/articles/PMC3873171/ /pubmed/24385714 http://dx.doi.org/10.4137/IJTR.S13371 Text en © 2013 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Original Research
Noakes, Rowland
Mellick, Nick
Immunohistochemical Studies of the Kynurenine Pathway in Morphea
title Immunohistochemical Studies of the Kynurenine Pathway in Morphea
title_full Immunohistochemical Studies of the Kynurenine Pathway in Morphea
title_fullStr Immunohistochemical Studies of the Kynurenine Pathway in Morphea
title_full_unstemmed Immunohistochemical Studies of the Kynurenine Pathway in Morphea
title_short Immunohistochemical Studies of the Kynurenine Pathway in Morphea
title_sort immunohistochemical studies of the kynurenine pathway in morphea
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873171/
https://www.ncbi.nlm.nih.gov/pubmed/24385714
http://dx.doi.org/10.4137/IJTR.S13371
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