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Phenome-Wide Association Studies on a Quantitative Trait: Application to TPMT Enzyme Activity and Thiopurine Therapy in Pharmacogenomics

Phenome-Wide Association Studies (PheWAS) investigate whether genetic polymorphisms associated with a phenotype are also associated with other diagnoses. In this study, we have developed new methods to perform a PheWAS based on ICD-10 codes and biological test results, and to use a quantitative trai...

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Detalles Bibliográficos
Autores principales:	Neuraz, Antoine, Chouchana, Laurent, Malamut, Georgia, Le Beller, Christine, Roche, Denis, Beaune, Philippe, Degoulet, Patrice, Burgun, Anita, Loriot, Marie-Anne, Avillach, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873228/ https://www.ncbi.nlm.nih.gov/pubmed/24385893 http://dx.doi.org/10.1371/journal.pcbi.1003405

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