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Analysis of TET Expression/Activity and 5mC Oxidation during Normal and Malignant Germ Cell Development

During mammalian development the fertilized zygote and primordial germ cells lose their DNA methylation within one cell cycle leading to the concept of active DNA demethylation. Recent studies identified the TET hydroxylases as key enzymes responsible for active DNA demethylation, catalyzing the oxi...

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Detalles Bibliográficos
Autores principales:	Nettersheim, Daniel, Heukamp, Lukas C., Fronhoffs, Florian, Grewe, Marc J., Haas, Natalie, Waha, Anke, Honecker, Friedemann, Waha, Andreas, Kristiansen, Glen, Schorle, Hubert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873252/ https://www.ncbi.nlm.nih.gov/pubmed/24386123 http://dx.doi.org/10.1371/journal.pone.0082881

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