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Defining Normal Liver Stiffness Range in a Normal Healthy Chinese Population without Liver Disease
BACKGROUND: For patients with chronic liver disease, different optimal liver stiffness cut-off values correspond to different stages of fibrosis, which are specific for the underlying liver disease and population. AIMS: To establish the normal ranges of liver stiffness in the healthy Chinese populat...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873442/ https://www.ncbi.nlm.nih.gov/pubmed/24386446 http://dx.doi.org/10.1371/journal.pone.0085067 |
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author | Fung, James Lee, Cheuk-kwong Chan, Monica Seto, Wai-kay Wong, Danny Ka-ho Lai, Ching-lung Yuen, Man-fung |
author_facet | Fung, James Lee, Cheuk-kwong Chan, Monica Seto, Wai-kay Wong, Danny Ka-ho Lai, Ching-lung Yuen, Man-fung |
author_sort | Fung, James |
collection | PubMed |
description | BACKGROUND: For patients with chronic liver disease, different optimal liver stiffness cut-off values correspond to different stages of fibrosis, which are specific for the underlying liver disease and population. AIMS: To establish the normal ranges of liver stiffness in the healthy Chinese population without underlying liver disease. METHODS: This is a prospective cross sectional study of 2,528 healthy volunteers recruited from the general population and the Red Cross Transfusion Center in Hong Kong. All participants underwent a comprehensive questionnaire survey, measurement of weight, height, and blood pressure. Fasting liver function tests, glucose and cholesterol was performed. Abdominal ultrasound and transient elastography were performed on all participants. RESULTS: Of the 2,528 subjects, 1,998 were excluded with either abnormal liver parenchyma on ultrasound, chronic medical condition, abnormal blood tests including liver enzymes, fasting glucose, fasting cholesterol, high body mass index, high blood pressure, or invalid liver stiffness scan. The reference range for the 530 subjects without known liver disease was 2.3 to 5.9 kPa (mean 4.1, SD 0.89). The median liver stiffness was higher in males compared with females (4.3 vs 4.0 kPa respectively, p<0.001). There was also a decline in median Lliver stiffness in the older age group, from 4.2 kPa in those <25 years to 3.4 kPa for those >55 years (p=0.001). CONCLUSIONS: The healthy reference range for liver stiffness in the Chinese population is 2.3 to 5.9 kPa. Female gender and older age group was associated with a lower median liver stiffness. |
format | Online Article Text |
id | pubmed-3873442 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38734422014-01-02 Defining Normal Liver Stiffness Range in a Normal Healthy Chinese Population without Liver Disease Fung, James Lee, Cheuk-kwong Chan, Monica Seto, Wai-kay Wong, Danny Ka-ho Lai, Ching-lung Yuen, Man-fung PLoS One Research Article BACKGROUND: For patients with chronic liver disease, different optimal liver stiffness cut-off values correspond to different stages of fibrosis, which are specific for the underlying liver disease and population. AIMS: To establish the normal ranges of liver stiffness in the healthy Chinese population without underlying liver disease. METHODS: This is a prospective cross sectional study of 2,528 healthy volunteers recruited from the general population and the Red Cross Transfusion Center in Hong Kong. All participants underwent a comprehensive questionnaire survey, measurement of weight, height, and blood pressure. Fasting liver function tests, glucose and cholesterol was performed. Abdominal ultrasound and transient elastography were performed on all participants. RESULTS: Of the 2,528 subjects, 1,998 were excluded with either abnormal liver parenchyma on ultrasound, chronic medical condition, abnormal blood tests including liver enzymes, fasting glucose, fasting cholesterol, high body mass index, high blood pressure, or invalid liver stiffness scan. The reference range for the 530 subjects without known liver disease was 2.3 to 5.9 kPa (mean 4.1, SD 0.89). The median liver stiffness was higher in males compared with females (4.3 vs 4.0 kPa respectively, p<0.001). There was also a decline in median Lliver stiffness in the older age group, from 4.2 kPa in those <25 years to 3.4 kPa for those >55 years (p=0.001). CONCLUSIONS: The healthy reference range for liver stiffness in the Chinese population is 2.3 to 5.9 kPa. Female gender and older age group was associated with a lower median liver stiffness. Public Library of Science 2013-12-26 /pmc/articles/PMC3873442/ /pubmed/24386446 http://dx.doi.org/10.1371/journal.pone.0085067 Text en © 2013 Fung et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Fung, James Lee, Cheuk-kwong Chan, Monica Seto, Wai-kay Wong, Danny Ka-ho Lai, Ching-lung Yuen, Man-fung Defining Normal Liver Stiffness Range in a Normal Healthy Chinese Population without Liver Disease |
title | Defining Normal Liver Stiffness Range in a Normal Healthy Chinese Population without Liver Disease |
title_full | Defining Normal Liver Stiffness Range in a Normal Healthy Chinese Population without Liver Disease |
title_fullStr | Defining Normal Liver Stiffness Range in a Normal Healthy Chinese Population without Liver Disease |
title_full_unstemmed | Defining Normal Liver Stiffness Range in a Normal Healthy Chinese Population without Liver Disease |
title_short | Defining Normal Liver Stiffness Range in a Normal Healthy Chinese Population without Liver Disease |
title_sort | defining normal liver stiffness range in a normal healthy chinese population without liver disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873442/ https://www.ncbi.nlm.nih.gov/pubmed/24386446 http://dx.doi.org/10.1371/journal.pone.0085067 |
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