Cyclin A Degradation by Primate Cytomegalovirus Protein pUL21a Counters Its Innate Restriction of Virus Replication

Cyclin A is critical for cellular DNA synthesis and S phase progression of the cell cycle. Human cytomegalovirus (HCMV) can reduce cyclin A levels and block cellular DNA synthesis, and cyclin A overexpression can repress HCMV replication. This interaction has only been previously observed in HCMV as...

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Detalles Bibliográficos
Autores principales: Caffarelli, Nicolas, Fehr, Anthony R., Yu, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873445/
https://www.ncbi.nlm.nih.gov/pubmed/24385906
http://dx.doi.org/10.1371/journal.ppat.1003825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873445/
https://www.ncbi.nlm.nih.gov/pubmed/24385906
http://dx.doi.org/10.1371/journal.ppat.1003825

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