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Licensing Adaptive Immunity by NOD-Like Receptors
The innate immune system is composed of a diverse set of host defense molecules, physical barriers, and specialized leukocytes and is the primary form of immune defense against environmental insults. Another crucial role of innate immunity is to shape the long-lived adaptive immune response mediated...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873523/ https://www.ncbi.nlm.nih.gov/pubmed/24409181 http://dx.doi.org/10.3389/fimmu.2013.00486 |
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author | Liu, Dong Rhebergen, Anne Marie Eisenbarth, Stephanie C. |
author_facet | Liu, Dong Rhebergen, Anne Marie Eisenbarth, Stephanie C. |
author_sort | Liu, Dong |
collection | PubMed |
description | The innate immune system is composed of a diverse set of host defense molecules, physical barriers, and specialized leukocytes and is the primary form of immune defense against environmental insults. Another crucial role of innate immunity is to shape the long-lived adaptive immune response mediated by T and B lymphocytes. The activation of pattern recognition receptors (PRRs) from the Toll-like receptor family is now a classic example of innate immune molecules influencing adaptive immunity, resulting in effective antigen presentation to naïve T cells. More recent work suggests that the activation of another family of PRRs, the NOD-like receptors (NLRs), induces a different set of innate immune responses and accordingly, drives different aspects of adaptive immunity. Yet how this unusually diverse family of molecules (some without canonical PRR function) regulates immunity remains incompletely understood. In this review, we discuss the evidence for and against NLR activity orchestrating adaptive immune responses during infectious as well as non-infectious challenges. |
format | Online Article Text |
id | pubmed-3873523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-38735232014-01-09 Licensing Adaptive Immunity by NOD-Like Receptors Liu, Dong Rhebergen, Anne Marie Eisenbarth, Stephanie C. Front Immunol Immunology The innate immune system is composed of a diverse set of host defense molecules, physical barriers, and specialized leukocytes and is the primary form of immune defense against environmental insults. Another crucial role of innate immunity is to shape the long-lived adaptive immune response mediated by T and B lymphocytes. The activation of pattern recognition receptors (PRRs) from the Toll-like receptor family is now a classic example of innate immune molecules influencing adaptive immunity, resulting in effective antigen presentation to naïve T cells. More recent work suggests that the activation of another family of PRRs, the NOD-like receptors (NLRs), induces a different set of innate immune responses and accordingly, drives different aspects of adaptive immunity. Yet how this unusually diverse family of molecules (some without canonical PRR function) regulates immunity remains incompletely understood. In this review, we discuss the evidence for and against NLR activity orchestrating adaptive immune responses during infectious as well as non-infectious challenges. Frontiers Media S.A. 2013-12-27 /pmc/articles/PMC3873523/ /pubmed/24409181 http://dx.doi.org/10.3389/fimmu.2013.00486 Text en Copyright © 2013 Liu, Rhebergen and Eisenbarth. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Liu, Dong Rhebergen, Anne Marie Eisenbarth, Stephanie C. Licensing Adaptive Immunity by NOD-Like Receptors |
title | Licensing Adaptive Immunity by NOD-Like Receptors |
title_full | Licensing Adaptive Immunity by NOD-Like Receptors |
title_fullStr | Licensing Adaptive Immunity by NOD-Like Receptors |
title_full_unstemmed | Licensing Adaptive Immunity by NOD-Like Receptors |
title_short | Licensing Adaptive Immunity by NOD-Like Receptors |
title_sort | licensing adaptive immunity by nod-like receptors |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873523/ https://www.ncbi.nlm.nih.gov/pubmed/24409181 http://dx.doi.org/10.3389/fimmu.2013.00486 |
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