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A Platform to View Huntingtin Exon 1 Aggregation Flux in the Cell Reveals Divergent Influences from Chaperones hsp40 and hsp70

Our capacity for tracking how misfolded proteins aggregate inside a cell and how different aggregation states impact cell biology remains enigmatic. To address this, we built a new toolkit that enabled the high throughput tracking of individual cells enriched with polyglutamine-expanded Htt exon 1 (...

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Detalles Bibliográficos
Autores principales:	Ormsby, Angelique R., Ramdzan, Yasmin M., Mok, Yee-Foong, Jovanoski, Kristijan D., Hatters, Danny M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873573/ https://www.ncbi.nlm.nih.gov/pubmed/24196953 http://dx.doi.org/10.1074/jbc.M113.486944

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