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Thermic effect of a meal and appetite in adults: an individual participant data meta-analysis of meal-test trials

BACKGROUND: Thermic effect of a meal (TEF) has previously been suggested to influence appetite. OBJECTIVE: The aim of this study was to assess whether there is an association between appetite and TEF. Second, to examine whether protein intake is associated with TEF or appetite. DESIGN: Individual pa...

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Autores principales: Ravn, Anne-Marie, Gregersen, Nikolaj Ture, Christensen, Robin, Rasmussen, Lone Graasbøl, Hels, Ole, Belza, Anita, Raben, Anne, Larsen, Thomas Meinert, Toubro, Søren, Astrup, Arne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Co-Action Publishing 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873760/
https://www.ncbi.nlm.nih.gov/pubmed/24376394
http://dx.doi.org/10.3402/fnr.v57i0.19676
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author Ravn, Anne-Marie
Gregersen, Nikolaj Ture
Christensen, Robin
Rasmussen, Lone Graasbøl
Hels, Ole
Belza, Anita
Raben, Anne
Larsen, Thomas Meinert
Toubro, Søren
Astrup, Arne
author_facet Ravn, Anne-Marie
Gregersen, Nikolaj Ture
Christensen, Robin
Rasmussen, Lone Graasbøl
Hels, Ole
Belza, Anita
Raben, Anne
Larsen, Thomas Meinert
Toubro, Søren
Astrup, Arne
author_sort Ravn, Anne-Marie
collection PubMed
description BACKGROUND: Thermic effect of a meal (TEF) has previously been suggested to influence appetite. OBJECTIVE: The aim of this study was to assess whether there is an association between appetite and TEF. Second, to examine whether protein intake is associated with TEF or appetite. DESIGN: Individual participant data (IPD) meta-analysis on studies were performed at the Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark. Five randomized meal-test studies, with 111 participants, were included. The included studies measured energy expenditure (EE) in respiration chambers and pre- and postprandial appetite sensations using Visual Analog Scales (VAS). The primary meta-analysis was based on a generic-inverse variance random-effects model, pooling individual study Spearman's correlation coefficients, resulting in a combined r-value with 95% confidence interval (95% CI). The I (2) value quantifies the proportion (%) of the variation in point estimates due to among-study differences. RESULTS: The IPD meta-analysis found no association between satiety and TEF expressed as the incremental area under the curve (TEF(iAUC)) (r=0.06 [95% CI −0.16 to 0.28], P=0.58; I (2)=15.8%). Similarly, Composite Appetite Score (CAS) was not associated with TEF(iAUC) (r=0.08 [95% CI −0.12 to 0.28], P=0.45; I (2)=0%). Posthoc analyses showed no association between satiety or CAS and TEF expressed as a percentage of energy intake (EI) (P>0.49) or TEF expressed as a percentage of baseline EE (P>0.17). When adjusting for covariates, TEF(iAUC) was associated with protein intake (P=0.0085). CONCLUSIONS: This IPD meta-analysis found no evidence supporting an association between satiety or CAS and TEF at protein intakes ∼15 E% (range 11–30 E%).
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spelling pubmed-38737602013-12-27 Thermic effect of a meal and appetite in adults: an individual participant data meta-analysis of meal-test trials Ravn, Anne-Marie Gregersen, Nikolaj Ture Christensen, Robin Rasmussen, Lone Graasbøl Hels, Ole Belza, Anita Raben, Anne Larsen, Thomas Meinert Toubro, Søren Astrup, Arne Food Nutr Res Meta-Analyses BACKGROUND: Thermic effect of a meal (TEF) has previously been suggested to influence appetite. OBJECTIVE: The aim of this study was to assess whether there is an association between appetite and TEF. Second, to examine whether protein intake is associated with TEF or appetite. DESIGN: Individual participant data (IPD) meta-analysis on studies were performed at the Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark. Five randomized meal-test studies, with 111 participants, were included. The included studies measured energy expenditure (EE) in respiration chambers and pre- and postprandial appetite sensations using Visual Analog Scales (VAS). The primary meta-analysis was based on a generic-inverse variance random-effects model, pooling individual study Spearman's correlation coefficients, resulting in a combined r-value with 95% confidence interval (95% CI). The I (2) value quantifies the proportion (%) of the variation in point estimates due to among-study differences. RESULTS: The IPD meta-analysis found no association between satiety and TEF expressed as the incremental area under the curve (TEF(iAUC)) (r=0.06 [95% CI −0.16 to 0.28], P=0.58; I (2)=15.8%). Similarly, Composite Appetite Score (CAS) was not associated with TEF(iAUC) (r=0.08 [95% CI −0.12 to 0.28], P=0.45; I (2)=0%). Posthoc analyses showed no association between satiety or CAS and TEF expressed as a percentage of energy intake (EI) (P>0.49) or TEF expressed as a percentage of baseline EE (P>0.17). When adjusting for covariates, TEF(iAUC) was associated with protein intake (P=0.0085). CONCLUSIONS: This IPD meta-analysis found no evidence supporting an association between satiety or CAS and TEF at protein intakes ∼15 E% (range 11–30 E%). Co-Action Publishing 2013-12-23 /pmc/articles/PMC3873760/ /pubmed/24376394 http://dx.doi.org/10.3402/fnr.v57i0.19676 Text en © 2013 Anne-Marie Ravn et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Meta-Analyses
Ravn, Anne-Marie
Gregersen, Nikolaj Ture
Christensen, Robin
Rasmussen, Lone Graasbøl
Hels, Ole
Belza, Anita
Raben, Anne
Larsen, Thomas Meinert
Toubro, Søren
Astrup, Arne
Thermic effect of a meal and appetite in adults: an individual participant data meta-analysis of meal-test trials
title Thermic effect of a meal and appetite in adults: an individual participant data meta-analysis of meal-test trials
title_full Thermic effect of a meal and appetite in adults: an individual participant data meta-analysis of meal-test trials
title_fullStr Thermic effect of a meal and appetite in adults: an individual participant data meta-analysis of meal-test trials
title_full_unstemmed Thermic effect of a meal and appetite in adults: an individual participant data meta-analysis of meal-test trials
title_short Thermic effect of a meal and appetite in adults: an individual participant data meta-analysis of meal-test trials
title_sort thermic effect of a meal and appetite in adults: an individual participant data meta-analysis of meal-test trials
topic Meta-Analyses
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873760/
https://www.ncbi.nlm.nih.gov/pubmed/24376394
http://dx.doi.org/10.3402/fnr.v57i0.19676
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