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Thermic effect of a meal and appetite in adults: an individual participant data meta-analysis of meal-test trials
BACKGROUND: Thermic effect of a meal (TEF) has previously been suggested to influence appetite. OBJECTIVE: The aim of this study was to assess whether there is an association between appetite and TEF. Second, to examine whether protein intake is associated with TEF or appetite. DESIGN: Individual pa...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Co-Action Publishing
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873760/ https://www.ncbi.nlm.nih.gov/pubmed/24376394 http://dx.doi.org/10.3402/fnr.v57i0.19676 |
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author | Ravn, Anne-Marie Gregersen, Nikolaj Ture Christensen, Robin Rasmussen, Lone Graasbøl Hels, Ole Belza, Anita Raben, Anne Larsen, Thomas Meinert Toubro, Søren Astrup, Arne |
author_facet | Ravn, Anne-Marie Gregersen, Nikolaj Ture Christensen, Robin Rasmussen, Lone Graasbøl Hels, Ole Belza, Anita Raben, Anne Larsen, Thomas Meinert Toubro, Søren Astrup, Arne |
author_sort | Ravn, Anne-Marie |
collection | PubMed |
description | BACKGROUND: Thermic effect of a meal (TEF) has previously been suggested to influence appetite. OBJECTIVE: The aim of this study was to assess whether there is an association between appetite and TEF. Second, to examine whether protein intake is associated with TEF or appetite. DESIGN: Individual participant data (IPD) meta-analysis on studies were performed at the Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark. Five randomized meal-test studies, with 111 participants, were included. The included studies measured energy expenditure (EE) in respiration chambers and pre- and postprandial appetite sensations using Visual Analog Scales (VAS). The primary meta-analysis was based on a generic-inverse variance random-effects model, pooling individual study Spearman's correlation coefficients, resulting in a combined r-value with 95% confidence interval (95% CI). The I (2) value quantifies the proportion (%) of the variation in point estimates due to among-study differences. RESULTS: The IPD meta-analysis found no association between satiety and TEF expressed as the incremental area under the curve (TEF(iAUC)) (r=0.06 [95% CI −0.16 to 0.28], P=0.58; I (2)=15.8%). Similarly, Composite Appetite Score (CAS) was not associated with TEF(iAUC) (r=0.08 [95% CI −0.12 to 0.28], P=0.45; I (2)=0%). Posthoc analyses showed no association between satiety or CAS and TEF expressed as a percentage of energy intake (EI) (P>0.49) or TEF expressed as a percentage of baseline EE (P>0.17). When adjusting for covariates, TEF(iAUC) was associated with protein intake (P=0.0085). CONCLUSIONS: This IPD meta-analysis found no evidence supporting an association between satiety or CAS and TEF at protein intakes ∼15 E% (range 11–30 E%). |
format | Online Article Text |
id | pubmed-3873760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Co-Action Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-38737602013-12-27 Thermic effect of a meal and appetite in adults: an individual participant data meta-analysis of meal-test trials Ravn, Anne-Marie Gregersen, Nikolaj Ture Christensen, Robin Rasmussen, Lone Graasbøl Hels, Ole Belza, Anita Raben, Anne Larsen, Thomas Meinert Toubro, Søren Astrup, Arne Food Nutr Res Meta-Analyses BACKGROUND: Thermic effect of a meal (TEF) has previously been suggested to influence appetite. OBJECTIVE: The aim of this study was to assess whether there is an association between appetite and TEF. Second, to examine whether protein intake is associated with TEF or appetite. DESIGN: Individual participant data (IPD) meta-analysis on studies were performed at the Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark. Five randomized meal-test studies, with 111 participants, were included. The included studies measured energy expenditure (EE) in respiration chambers and pre- and postprandial appetite sensations using Visual Analog Scales (VAS). The primary meta-analysis was based on a generic-inverse variance random-effects model, pooling individual study Spearman's correlation coefficients, resulting in a combined r-value with 95% confidence interval (95% CI). The I (2) value quantifies the proportion (%) of the variation in point estimates due to among-study differences. RESULTS: The IPD meta-analysis found no association between satiety and TEF expressed as the incremental area under the curve (TEF(iAUC)) (r=0.06 [95% CI −0.16 to 0.28], P=0.58; I (2)=15.8%). Similarly, Composite Appetite Score (CAS) was not associated with TEF(iAUC) (r=0.08 [95% CI −0.12 to 0.28], P=0.45; I (2)=0%). Posthoc analyses showed no association between satiety or CAS and TEF expressed as a percentage of energy intake (EI) (P>0.49) or TEF expressed as a percentage of baseline EE (P>0.17). When adjusting for covariates, TEF(iAUC) was associated with protein intake (P=0.0085). CONCLUSIONS: This IPD meta-analysis found no evidence supporting an association between satiety or CAS and TEF at protein intakes ∼15 E% (range 11–30 E%). Co-Action Publishing 2013-12-23 /pmc/articles/PMC3873760/ /pubmed/24376394 http://dx.doi.org/10.3402/fnr.v57i0.19676 Text en © 2013 Anne-Marie Ravn et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Meta-Analyses Ravn, Anne-Marie Gregersen, Nikolaj Ture Christensen, Robin Rasmussen, Lone Graasbøl Hels, Ole Belza, Anita Raben, Anne Larsen, Thomas Meinert Toubro, Søren Astrup, Arne Thermic effect of a meal and appetite in adults: an individual participant data meta-analysis of meal-test trials |
title | Thermic effect of a meal and appetite in adults: an individual participant data meta-analysis of meal-test trials |
title_full | Thermic effect of a meal and appetite in adults: an individual participant data meta-analysis of meal-test trials |
title_fullStr | Thermic effect of a meal and appetite in adults: an individual participant data meta-analysis of meal-test trials |
title_full_unstemmed | Thermic effect of a meal and appetite in adults: an individual participant data meta-analysis of meal-test trials |
title_short | Thermic effect of a meal and appetite in adults: an individual participant data meta-analysis of meal-test trials |
title_sort | thermic effect of a meal and appetite in adults: an individual participant data meta-analysis of meal-test trials |
topic | Meta-Analyses |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873760/ https://www.ncbi.nlm.nih.gov/pubmed/24376394 http://dx.doi.org/10.3402/fnr.v57i0.19676 |
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