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Anti-Inflammatory Iridoids of Botanical Origin

Inflammation is a manifestation of a wide range of disorders which include; arthritis, atherosclerosis, Alzheimer’s disease, inflammatory bowel syndrome, physical injury and infection amongst many others. Common treatment modalities are usually non-steroidal anti-inflammatory drugs (NSAIDs) such as...

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Detalles Bibliográficos
Autores principales: Viljoen, A, Mncwangi, N, Vermaak, I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873812/
https://www.ncbi.nlm.nih.gov/pubmed/22414102
http://dx.doi.org/10.2174/092986712800229005
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author Viljoen, A
Mncwangi, N
Vermaak, I
author_facet Viljoen, A
Mncwangi, N
Vermaak, I
author_sort Viljoen, A
collection PubMed
description Inflammation is a manifestation of a wide range of disorders which include; arthritis, atherosclerosis, Alzheimer’s disease, inflammatory bowel syndrome, physical injury and infection amongst many others. Common treatment modalities are usually non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, paracetamol, indomethacin and ibuprofen as well as corticosteroids such as prednisone. These however, may be associated with a host of side effects due to non-selectivity for cyclooxygenase (COX) enzymes involved in inflammation and those with selectivity may be highly priced. Thus, there is a continuing search for safe and effective anti-inflammatory molecules from natural sources. Research has confirmed that iridoids exhibit promising anti-inflammatory activity which may be beneficial in the treatment of inflammation. Iridoids are secondary metabolites present in various plants, especially in species belonging to the Apocynaceae, Lamiaceae, Loganiaceae, Rubiaceae, Scrophulariaceae and Verbenaceae families. Many of these ethnobotanicals have an illustrious history of traditional use alluding to their use to treat inflammation. Although iridoids exhibit a wide range of pharmacological activities such as cardiovascular, hepatoprotection, hypoglycaemic, antimutagenic, antispasmodic, anti-tumour, antiviral, immunomodulation and purgative effects this review will acutely focus on their anti-inflammatory properties. The paper aims to present a summary for the most prominent iridoid-containing plants for which anti-inflammatory activity has been demonstrated in vitro and / or in vivo.
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spelling pubmed-38738122013-12-30 Anti-Inflammatory Iridoids of Botanical Origin Viljoen, A Mncwangi, N Vermaak, I Curr Med Chem Article Inflammation is a manifestation of a wide range of disorders which include; arthritis, atherosclerosis, Alzheimer’s disease, inflammatory bowel syndrome, physical injury and infection amongst many others. Common treatment modalities are usually non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, paracetamol, indomethacin and ibuprofen as well as corticosteroids such as prednisone. These however, may be associated with a host of side effects due to non-selectivity for cyclooxygenase (COX) enzymes involved in inflammation and those with selectivity may be highly priced. Thus, there is a continuing search for safe and effective anti-inflammatory molecules from natural sources. Research has confirmed that iridoids exhibit promising anti-inflammatory activity which may be beneficial in the treatment of inflammation. Iridoids are secondary metabolites present in various plants, especially in species belonging to the Apocynaceae, Lamiaceae, Loganiaceae, Rubiaceae, Scrophulariaceae and Verbenaceae families. Many of these ethnobotanicals have an illustrious history of traditional use alluding to their use to treat inflammation. Although iridoids exhibit a wide range of pharmacological activities such as cardiovascular, hepatoprotection, hypoglycaemic, antimutagenic, antispasmodic, anti-tumour, antiviral, immunomodulation and purgative effects this review will acutely focus on their anti-inflammatory properties. The paper aims to present a summary for the most prominent iridoid-containing plants for which anti-inflammatory activity has been demonstrated in vitro and / or in vivo. Bentham Science Publishers 2012-05 2012-05 /pmc/articles/PMC3873812/ /pubmed/22414102 http://dx.doi.org/10.2174/092986712800229005 Text en © Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Viljoen, A
Mncwangi, N
Vermaak, I
Anti-Inflammatory Iridoids of Botanical Origin
title Anti-Inflammatory Iridoids of Botanical Origin
title_full Anti-Inflammatory Iridoids of Botanical Origin
title_fullStr Anti-Inflammatory Iridoids of Botanical Origin
title_full_unstemmed Anti-Inflammatory Iridoids of Botanical Origin
title_short Anti-Inflammatory Iridoids of Botanical Origin
title_sort anti-inflammatory iridoids of botanical origin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873812/
https://www.ncbi.nlm.nih.gov/pubmed/22414102
http://dx.doi.org/10.2174/092986712800229005
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