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Adeno-Associated Viral Vector Serotype 5 Poorly Transduces Liver in Rat Models

Preclinical studies in mice and non-human primates showed that AAV serotype 5 provides efficient liver transduction and as such seems a promising vector for liver directed gene therapy. An advantage of AAV5 compared to serotype 8 already shown to provide efficient correction in a phase 1 trial in pa...

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Detalles Bibliográficos
Autores principales:	Montenegro-Miranda, Paula S., Pañeda, Astrid, ten Bloemendaal, Lysbeth, Duijst, Suzanne, de Waart, Dirk R., Aseguinolaza, Gloria Gonzalez, Bosma, Piter J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873922/ https://www.ncbi.nlm.nih.gov/pubmed/24386104 http://dx.doi.org/10.1371/journal.pone.0082597

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