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Magnetic Resonance Findings of the Corpus Callosum in Canine and Feline Lysosomal Storage Diseases

Several reports have described magnetic resonance (MR) findings in canine and feline lysosomal storage diseases such as gangliosidoses and neuronal ceroid lipofuscinosis. Although most of those studies described the signal intensities of white matter in the cerebrum, findings of the corpus callosum...

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Autores principales: Hasegawa, Daisuke, Tamura, Shinji, Nakamoto, Yuya, Matsuki, Naoaki, Takahashi, Kimimasa, Fujita, Michio, Uchida, Kazuyuki, Yamato, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873931/
https://www.ncbi.nlm.nih.gov/pubmed/24386203
http://dx.doi.org/10.1371/journal.pone.0083455
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author Hasegawa, Daisuke
Tamura, Shinji
Nakamoto, Yuya
Matsuki, Naoaki
Takahashi, Kimimasa
Fujita, Michio
Uchida, Kazuyuki
Yamato, Osamu
author_facet Hasegawa, Daisuke
Tamura, Shinji
Nakamoto, Yuya
Matsuki, Naoaki
Takahashi, Kimimasa
Fujita, Michio
Uchida, Kazuyuki
Yamato, Osamu
author_sort Hasegawa, Daisuke
collection PubMed
description Several reports have described magnetic resonance (MR) findings in canine and feline lysosomal storage diseases such as gangliosidoses and neuronal ceroid lipofuscinosis. Although most of those studies described the signal intensities of white matter in the cerebrum, findings of the corpus callosum were not described in detail. A retrospective study was conducted on MR findings of the corpus callosum as well as the rostral commissure and the fornix in 18 cases of canine and feline lysosomal storage diseases. This included 6 Shiba Inu dogs and 2 domestic shorthair cats with GM1 gangliosidosis; 2 domestic shorthair cats, 2 familial toy poodles, and a golden retriever with GM2 gangliosidosis; and 2 border collies and 3 chihuahuas with neuronal ceroid lipofuscinoses, to determine whether changes of the corpus callosum is an imaging indicator of those diseases. The corpus callosum and the rostral commissure were difficult to recognize in all cases of juvenile-onset gangliosidoses (GM1 gangliosidosis in Shiba Inu dogs and domestic shorthair cats and GM2 gangliosidosis in domestic shorthair cats) and GM2 gangliosidosis in toy poodles with late juvenile-onset. In contrast, the corpus callosum and the rostral commissure were confirmed in cases of GM2 gangliosidosis in a golden retriever and canine neuronal ceroid lipofuscinoses with late juvenile- to early adult-onset, but were extremely thin. Abnormal findings of the corpus callosum on midline sagittal images may be a useful imaging indicator for suspecting lysosomal storage diseases, especially hypoplasia (underdevelopment) of the corpus callosum in juvenile-onset gangliosidoses.
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spelling pubmed-38739312014-01-02 Magnetic Resonance Findings of the Corpus Callosum in Canine and Feline Lysosomal Storage Diseases Hasegawa, Daisuke Tamura, Shinji Nakamoto, Yuya Matsuki, Naoaki Takahashi, Kimimasa Fujita, Michio Uchida, Kazuyuki Yamato, Osamu PLoS One Research Article Several reports have described magnetic resonance (MR) findings in canine and feline lysosomal storage diseases such as gangliosidoses and neuronal ceroid lipofuscinosis. Although most of those studies described the signal intensities of white matter in the cerebrum, findings of the corpus callosum were not described in detail. A retrospective study was conducted on MR findings of the corpus callosum as well as the rostral commissure and the fornix in 18 cases of canine and feline lysosomal storage diseases. This included 6 Shiba Inu dogs and 2 domestic shorthair cats with GM1 gangliosidosis; 2 domestic shorthair cats, 2 familial toy poodles, and a golden retriever with GM2 gangliosidosis; and 2 border collies and 3 chihuahuas with neuronal ceroid lipofuscinoses, to determine whether changes of the corpus callosum is an imaging indicator of those diseases. The corpus callosum and the rostral commissure were difficult to recognize in all cases of juvenile-onset gangliosidoses (GM1 gangliosidosis in Shiba Inu dogs and domestic shorthair cats and GM2 gangliosidosis in domestic shorthair cats) and GM2 gangliosidosis in toy poodles with late juvenile-onset. In contrast, the corpus callosum and the rostral commissure were confirmed in cases of GM2 gangliosidosis in a golden retriever and canine neuronal ceroid lipofuscinoses with late juvenile- to early adult-onset, but were extremely thin. Abnormal findings of the corpus callosum on midline sagittal images may be a useful imaging indicator for suspecting lysosomal storage diseases, especially hypoplasia (underdevelopment) of the corpus callosum in juvenile-onset gangliosidoses. Public Library of Science 2013-12-27 /pmc/articles/PMC3873931/ /pubmed/24386203 http://dx.doi.org/10.1371/journal.pone.0083455 Text en © 2013 Hasegawa et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hasegawa, Daisuke
Tamura, Shinji
Nakamoto, Yuya
Matsuki, Naoaki
Takahashi, Kimimasa
Fujita, Michio
Uchida, Kazuyuki
Yamato, Osamu
Magnetic Resonance Findings of the Corpus Callosum in Canine and Feline Lysosomal Storage Diseases
title Magnetic Resonance Findings of the Corpus Callosum in Canine and Feline Lysosomal Storage Diseases
title_full Magnetic Resonance Findings of the Corpus Callosum in Canine and Feline Lysosomal Storage Diseases
title_fullStr Magnetic Resonance Findings of the Corpus Callosum in Canine and Feline Lysosomal Storage Diseases
title_full_unstemmed Magnetic Resonance Findings of the Corpus Callosum in Canine and Feline Lysosomal Storage Diseases
title_short Magnetic Resonance Findings of the Corpus Callosum in Canine and Feline Lysosomal Storage Diseases
title_sort magnetic resonance findings of the corpus callosum in canine and feline lysosomal storage diseases
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873931/
https://www.ncbi.nlm.nih.gov/pubmed/24386203
http://dx.doi.org/10.1371/journal.pone.0083455
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