Characterization of Two Distinct Lymphoproliferative Diseases Caused by Ectopic Expression of the Notch Ligand DLL4 on T Cells

Notch signaling is essential for the development of T cell progenitors through the interaction of NOTCH1 receptor on their surface with the ligand, Delta-like 4 (DLL4), which is expressed by the thymic epithelial cells. Notch signaling is quickly shut down once the cells pass β-selection, and CD4/CD...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiong, Huizhong, Maraver, Antonio, Latkowski, Jo-Ann, Henderson, Tanya, Schlessinger, Karni, Ding, Yi, Shen, Jie, Tadokoro, Carlos E., Lafaille, Juan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874025/
https://www.ncbi.nlm.nih.gov/pubmed/24386421
http://dx.doi.org/10.1371/journal.pone.0084841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874025/
https://www.ncbi.nlm.nih.gov/pubmed/24386421
http://dx.doi.org/10.1371/journal.pone.0084841

Ejemplares similares