Human telomeres that carry an integrated copy of human herpesvirus 6 are often short and unstable, facilitating release of the viral genome from the chromosome

Linear chromosomes are stabilized by telomeres, but the presence of short dysfunctional telomeres triggers cellular senescence in human somatic tissues, thus contributing to ageing. Approximately 1% of the population inherits a chromosomally integrated copy of human herpesvirus 6 (CI-HHV-6), but the...

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Detalles Bibliográficos
Autores principales: Huang, Yan, Hidalgo-Bravo, Alberto, Zhang, Enjie, Cotton, Victoria E., Mendez-Bermudez, Aaron, Wig, Gunjan, Medina-Calzada, Zahara, Neumann, Rita, Jeffreys, Alec J., Winney, Bruce, Wilson, James F., Clark, Duncan A., Dyer, Martin J., Royle, Nicola J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874159/
https://www.ncbi.nlm.nih.gov/pubmed/24057213
http://dx.doi.org/10.1093/nar/gkt840

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