Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells

How tumor suppressor p53 selectively responds to specific signals, especially in normal cells, is poorly understood. We performed genome-wide profiling of p53 chromatin interactions and target gene expression in human embryonic stem cells (hESCs) in response to early differentiation, induced by reti...

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Detalles Bibliográficos
Autores principales: Akdemir, Kadir C., Jain, Abhinav K., Allton, Kendra, Aronow, Bruce, Xu, Xueping, Cooney, Austin J., Li, Wei, Barton, Michelle Craig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874181/
https://www.ncbi.nlm.nih.gov/pubmed/24078252
http://dx.doi.org/10.1093/nar/gkt866

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