Inactivating CUX1 mutations promote tumorigenesis

A major challenge for cancer genetics is to determine which low frequency somatic mutations are drivers of tumorigenesis. Here we interrogate the genomes of 7,651 diverse human cancers to identify novel drivers and find inactivating mutations in the homeodomain transcription factor CUX1 (cut-like ho...

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Detalles Bibliográficos
Autores principales: Wong, Chi C., Martincorena, Inigo, Rust, Alistair G., Rashid, Mamunur, Alifrangis, Constantine, Alexandrov, Ludmil B., Tiffen, Jessamy C., Kober, Christina, Green, Anthony R., Massie, Charles E., Nangalia, Jyoti, Lempidaki, Stella, Döhner, Hartmut, Döhner, Konstanze, Bray, Sarah J., McDermott, Ultan, Papaemmanuil, Elli, Campbell, Peter J., Adams, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874239/
https://www.ncbi.nlm.nih.gov/pubmed/24316979
http://dx.doi.org/10.1038/ng.2846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874239/
https://www.ncbi.nlm.nih.gov/pubmed/24316979
http://dx.doi.org/10.1038/ng.2846

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