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Sporadic Hemiplegic Migraine with ATP1A2 and Prothrombin Gene Mutations
Background. Hemiplegic migraine is a rare type of migraine that may present in children and adolescents. Both familial and sporadic hemiplegic migraines have similar prevalence and clinical characteristics. Patient. We report an adolescent with sporadic hemiplegic migraine who previously had a simil...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874315/ https://www.ncbi.nlm.nih.gov/pubmed/24396618 http://dx.doi.org/10.1155/2013/895057 |
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author | Aceves, Jose Mungall, Diana Kirmani, Batool F. |
author_facet | Aceves, Jose Mungall, Diana Kirmani, Batool F. |
author_sort | Aceves, Jose |
collection | PubMed |
description | Background. Hemiplegic migraine is a rare type of migraine that may present in children and adolescents. Both familial and sporadic hemiplegic migraines have similar prevalence and clinical characteristics. Patient. We report an adolescent with sporadic hemiplegic migraine who previously had a similar attack in the past and who was initially evaluated for a possible acute ischemic event. Results. Magnetic resonance angiography showed dilatation of the left middle cerebral artery that resolved in a follow-up study. She was also found to have a ATP1A2 (c.2273 G>C) mutation and a heterozygous prothrombin mutation. Conclusions. We suggest that patients with sporadic hemiplegic migraine be tested for both ATP1A2 mutations which in some cases may be pathogenic, and prothrombin mutations which increase the stroke risk for this patient population. |
format | Online Article Text |
id | pubmed-3874315 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38743152014-01-06 Sporadic Hemiplegic Migraine with ATP1A2 and Prothrombin Gene Mutations Aceves, Jose Mungall, Diana Kirmani, Batool F. Case Rep Neurol Med Case Report Background. Hemiplegic migraine is a rare type of migraine that may present in children and adolescents. Both familial and sporadic hemiplegic migraines have similar prevalence and clinical characteristics. Patient. We report an adolescent with sporadic hemiplegic migraine who previously had a similar attack in the past and who was initially evaluated for a possible acute ischemic event. Results. Magnetic resonance angiography showed dilatation of the left middle cerebral artery that resolved in a follow-up study. She was also found to have a ATP1A2 (c.2273 G>C) mutation and a heterozygous prothrombin mutation. Conclusions. We suggest that patients with sporadic hemiplegic migraine be tested for both ATP1A2 mutations which in some cases may be pathogenic, and prothrombin mutations which increase the stroke risk for this patient population. Hindawi Publishing Corporation 2013 2013-12-11 /pmc/articles/PMC3874315/ /pubmed/24396618 http://dx.doi.org/10.1155/2013/895057 Text en Copyright © 2013 Jose Aceves et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Aceves, Jose Mungall, Diana Kirmani, Batool F. Sporadic Hemiplegic Migraine with ATP1A2 and Prothrombin Gene Mutations |
title | Sporadic Hemiplegic Migraine with ATP1A2 and Prothrombin Gene Mutations |
title_full | Sporadic Hemiplegic Migraine with ATP1A2 and Prothrombin Gene Mutations |
title_fullStr | Sporadic Hemiplegic Migraine with ATP1A2 and Prothrombin Gene Mutations |
title_full_unstemmed | Sporadic Hemiplegic Migraine with ATP1A2 and Prothrombin Gene Mutations |
title_short | Sporadic Hemiplegic Migraine with ATP1A2 and Prothrombin Gene Mutations |
title_sort | sporadic hemiplegic migraine with atp1a2 and prothrombin gene mutations |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874315/ https://www.ncbi.nlm.nih.gov/pubmed/24396618 http://dx.doi.org/10.1155/2013/895057 |
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